Dan V. Iosifescu, MD

JCP
Rapidity of Improvement With Intranasal Esketamine for MDD
Meta-Analysis

December 12, 2022

This meta-analysis found that augmenting antidepressants with intranasal esketamine vs placebo was more effective in reducing depression severity at 24 hours and study endpoint.
Rebecca S. Hock, Anna Feeney, Nadia Iovieno, et al
JCP
Effect of Benzodiazepines on Antidepressant Effects of Ketamine
Original Research

November 14, 2022

Findings of studies examining the impact of benzodiazepines on antidepressant effects of ketamine are contradictory. This study assessed whether concomitant oral benzodiazepines differentially affected treatment response to ketamine versus...
Anna Feeney, Bettina B. Hoeppner, Marlene P. Freeman, et al
JCP
Very Low-Level Transcranial Photobiomodulation for MDD
Original Research

August 8, 2022

Transcranial photobiomodulation may be efficacious for major depressive disorder, but the optimal dose is not known. Here, a very low dose was studied to establish a threshold for lack...
Dan V. Iosifescu, Richard J. Norton, Umit Tural, et al
JCP
Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in MDD
Original Research

May 30, 2022

Altered glutamatergic neurotransmission has been implicated in the pathogenesis of depression. This phase 3 trial evaluated the efficacy and safety of AXS-05 (dextromethorphan-bupropion) in the treatment of major depressive...
Dan V. Iosifescu, Amanda Jones, Cedric O’Gorman, et al
JCP
ASCP Corner

January 19, 2021

The question of whether, and when, antidepressants are appropriate in bipolar disorder is a hotly debated topic. This ASCP Corner article summarizes the key concepts with greatest relevance for...
Joseph F. Goldberg, Andrew A. Nierenberg, Dan V. Iosifescu
JCP
Meta-Analysis

May 26, 2020

The FDA has now approved intranasal esketamine as augmention in treatment-resistant depression, and recent studies of its efficacy have been encouraging. This meta-analysis synthesizes the evidence to provide an...
George I. Papakostas, Naji C. Salloum, Rebecca S. Hock, et al
JCP
Commentary

June 24, 2015

Dan V. Iosifescu
JCP
Original Research

September 2, 2014

Le-Ben Wan, Cara F. Levitch, Andrew M. Perez, et al
JCP
Original Research

July 15, 2013

Cristina Cusin, Nadia Iovieno, Dan V. Iosifescu, et al
JCP
Original Research

January 15, 2013

Ian A. Cook, Aimee M. Hunter, William S. Gilmer, et al
JCP
Original Research

November 2, 2010

Maurizio Fava, Kendyl Schaefer, Holly Huang, et al
JCP
Original Research

November 15, 2006

Maurizio Fava, Lesley M. Graves, Franco Benazzi, et al

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