Jose de Leon, MD | Psychiatrist.com

Best Practices for Switching to Clozapine in Patients With Schizophrenia

ASCP Corner

Best Practices for Switching to Clozapine in Patients With Schizophrenia

July 4, 2022

This article provides expert advice on dosage and timing when switching from a prior medication to clozapine in patients with schizophrenia.

Georgios Schoretsanitis, Jose de Leon

Letter to the Editor

Comment on Pharmacogenetics Section of Recent Genetics Guideline

April 9, 2019

In this letter to the editor, Dr de Leon comments on the recent article "What Should a Psychiatrist Know About Genetics?" by Nurnberger et al.

Jose de Leon

Letter to the Editor

Lorazepam Tolerance Within 48 Hours

May 17, 2018

Benzodiazepine tolerance after multiple days or weeks has been described—but not within 48 hours. Read this report of a man with catatonia who rapidly developed tolerance to lorazepam in...

Nasratullah Wahidi, Jose de Leon

Letter to the Editor

Unexpected Falls, Clozapine Treatment, and Myoclonus

January 18, 2018

Clozapine can cause falls due to orthostatic hypotension or sedation, particularly in geriatric patients. A less-recognized cause of falls in clozapine patients is myoclonus, which manifests as knee buckling...

Betsy McCollum, Jaqueline Barclay, Jose de Leon

Letter to the Editor

Moria—Not From Tolkien's Middle Earth

August 3, 2017

It took 6 years for this patient with pathological giddiness to trek through a morass of specialists and find the proper diagnosis of moria, a condition perhaps most commonly...

Victoria C. de Leon, John Bilbily, Charles Shelton, et al

Meta-Analysis

Clozapine Augmentation With Antiepileptic Drugs

May 24, 2017

Only 30% to 60% of patients with treatment-resistant schizophrenia benefit from clozapine monotherapy. Does augmentation with mood stabilizers/antiepileptics improve the chances of success? This meta-analysis of 22 randomized controlled...

Wei Zheng, Yu-Tao Xiang, Xin-Hu Yang, et al

Article

A Cross-Sectional Study of Major Repeaters: A Distinct Phenotype of Suicidal Behavior

August 15, 2014

Can people become addicted to suicidal behavior? Read this journal CME article to learn more about the demographic and clinical characteristics of patients who repeatedly attempt suicide.

Hilario Blasco-Fontecilla, Isabelle Jaussent, Emilie Olié, et al

Letter to the Editor

Pharmacokinetic Drug-Drug Interactions Between Olanzapine and Valproate Need to Be Better Studied

July 15, 2010

Jose de Leon, Francisco J. Diaz, Edoardo Spina

Letter to the Editor

How Should Research Productivity Be Assessed in Early Career Psychiatric Researchers? Research Funding Versus Scientific Productivity

September 15, 2009

Jose de Leon

Original Research

Low Serum Cholesterol May Be Associated With Suicide Attempt History

December 31, 2008

M. Mercedes Perez-Rodriguez, Enrique Baca-García, Carmen Diaz-Sastre, et al

Article

Commentary: Smoking Cessation in Patients With Psychiatric Disorders

February 14, 2008

Alan J. Gelenberg, Jose de Leon, A. Eden Evins, et al

Original Research

Smoking Cessation in Patients With Psychiatric Disorders

September 17, 2007

Alan J. Gelenberg, Jose de Leon, A. Eden Evins, et al

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