Sara De Martin, PhD | Psychiatrist.com

Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants

Original Research

Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants

June 17, 2024

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.

Maurizio Fava, Stephen M. Stahl, Luca Pani, et al

Effect of Time From Onset of MDD on Response to Esmethadone

Original Research

Effect of Time From Onset of MDD on Response to Esmethadone

May 13, 2024

Esmethadone 25 and 50 mg were more effective in reducing depression scale scores in patients who had a shorter time since their first major depressive episode.

Clotilde Guidetti, Sara De Martin, Giulia Serra, et al

REL-1017 Effects on Cognition in MDD

Original Research

REL-1017 Effects on Cognition in MDD

February 14, 2023

REL-1017 improved subjective measures of cognitive impairment, in addition to improving total MADRS and SDQ scores.

Clotilde Guidetti, Giulia Serra, Luca Pani, et al