Case Report

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PCC
Managing 7-hydroxymitragynine Withdrawal
Case Report

Managing 7-hydroxymitragynine Withdrawal

August 27, 2026

A 49-year-old man taking “7-OH” experienced significant opioid withdrawal symptoms that resolved with high-dose buprenorphine-naloxone treatment.
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PCC
Aripiprazole-Induced Hiccups
Case Report

Aripiprazole-Induced Hiccups

August 25, 2026

A 29-year-old man hospitalized for psychotic symptoms in the context of methamphetamine experienced persistent hiccups after starting aripiprazole.
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PCC
Renal Agenesis, Dysmorphism, and Schizophrenia
Case Report

Renal Agenesis, Dysmorphism, and Schizophrenia

August 18, 2026

The authors report a case of treatment-resistant schizophrenia with unilateral renal agenesis and minor physical anomalies, highlighting this rare association as well as treatment implications.
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PCC
Unexpected Improvement in Obsessive-Compulsive Disorder Symptoms Following Initiation of Bupropion
Case Report

Unexpected Improvement in Obsessive-Compulsive Disorder Symptoms Following Initiation of Bupropion

August 18, 2026

A 23-year-old woman with OCD and comorbid depression experienced an unexpected improvement in OCD symptoms following initiation of bupropion.
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PCC
Peduncular Hallucinosis With Right Thalamic Cavernous Angioma
Case Report

Peduncular Hallucinosis With Right Thalamic Cavernous Angioma

August 18, 2026

A 56-year-old woman developed visual and auditory hallucinations, delusions of jealousy and possession, and cognitive impairment associated with a thalamic lesion
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PCC
Volitional Mutism in Adulthood
Case Report

Volitional Mutism in Adulthood

August 6, 2026

The authors present a case of volitional mutism in a 42-year-old woman and highlight the differential diagnosis.
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Recent JCP Articles on Case Report

JCP
Oral Glutamatergic Modulation with Dextromethorphan and Piracetam for Refractory Bipolar Disorder With OCD
Case Report

Oral Glutamatergic Modulation with Dextromethorphan and Piracetam for Refractory Bipolar Disorder With OCD

February 23, 2026

Three patients with combined bipolar disorder and OCD experienced remission of depressive, anxious, and obsessive-compulsive symptoms after piracetam was added to dextromethorphan.
JCP
Zuranolone for Postpartum Depression in Real-World Clinical Practice
Case Report

Zuranolone for Postpartum Depression in Real-World Clinical Practice

July 2, 2025

Three cases of successful treatment of postpartum depression with zuranolone are presented and discussed.
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JCP
Administering Semaglutide With Long-Term Olanzapine Use
Case Report

Administering Semaglutide With Long-Term Olanzapine Use

June 9, 2025

This report describes use of the GLP-1R agonist semaglutide in a patient with schizophrenia and severe, olanzapine-induced weight gain that was resistant to alternative treatments.
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Recent PCC Articles on Case Report

PCC
Mirtazapine-Induced Severe Hyponatremia
Case Report

Mirtazapine-Induced Severe Hyponatremia

July 16, 2026

A 30-year-old man developed severe hyponatremia after starting mirtazapine, highlighting the importance of closely monitoring sodium levels when starting any antidepressant in patients already taking oxcarbazepine.
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PCC
Cocaine-Associated Rectal Foreign Body Insertion
Case Report

Cocaine-Associated Rectal Foreign Body Insertion

July 16, 2026

This case highlights how recurrent surgical presentations related to substance-associated compulsive behavior can outpace sustained, longitudinal behavioral intervention, particularly when psychiatric and addiction care are not integrated early.
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PCC
Freeze Attacks in Stiff Person Spectrum Disorder
Case Report

Freeze Attacks in Stiff Person Spectrum Disorder

July 14, 2026

A 43-year-old woman with stiff person spectrum disorder developed agoraphobia after "freeze attacks" in public, highlighting the need to screen these patients for anxiety and the role of CBT...
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Featured Case Report Research

JCP
Obstetric Risk Associated with Stimulant vs Nonstimulant Treatment
Original Research

Obstetric Risk Associated with Stimulant vs Nonstimulant Treatment

August 26, 2026

Stimulant and nonstimulant use during pregnancy were both associated with increased risk for obstetric complications vs no medication.
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JCP
ADHD Medication Safety in Pregnancy: Precise Estimates, Uncertain Causal Inference
Commentary

ADHD Medication Safety in Pregnancy: Precise Estimates, Uncertain Causal Inference

August 26, 2026

Comments on a recent study by Babinski and Tuan finding ADHD medication use predictive of adverse pregnancy outcomes.
JCP
The Prescriber’s Guide to Oral Ketamine for Depression
Clinical and Practical Psychopharmacology

The Prescriber’s Guide to Oral Ketamine for Depression

August 26, 2026

Explains clinical contexts in which oral ketamine can be used and presents a detailed protocol for the use of this intervention.
PCC
Mushroom-Based Supplement Worsens Psychosis
Case Report

Mushroom-Based Supplement Worsens Psychosis

August 4, 2026

This case illustrates potential neuropsychiatric risks associated with mushroom-based dietary supplements in individuals with neurological vulnerabilities such as cerebral palsy.
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PCC
Testosterone-Induced Psychosis in Klinefelter Syndrome
Case Report

Testosterone-Induced Psychosis in Klinefelter Syndrome

July 30, 2026

The authors report a rare case of acute psychosis following long-term parenteral testosterone replacement in a patient with undiagnosed Klinefelter syndrome.
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PCC
Abrupt Smoking Cessation With Tirzepatide
Case Report

Abrupt Smoking Cessation With Tirzepatide

July 30, 2026

The authors present a case of sudden, sustained smoking cessation associated with the initiation of tirzepatide in a 53-year-old woman.
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PCC
Decision-Making Capacity in the Operating Room
Case Report

Decision-Making Capacity in the Operating Room

July 28, 2026

This case illustrates that patients may retain decision-making even when refusing life-sustaining interventions in emergent contexts
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PCC
Amiodarone-Induced Thyrotoxicosis and Mania
Case Report

Amiodarone-Induced Thyrotoxicosis and Mania

July 28, 2026

A 66-year-old man diagnosed with amiodarone-induced thyrotoxicosis who presented to the emergency department with symptoms of mania.
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PCC
Modafinil for Hypoactive Delirium in the ICU
Case Report

Modafinil for Hypoactive Delirium in the ICU

July 21, 2026

A 57-year-old woman with severe hypoactive delirium rapidly improved following a split-dosing strategy of modafinil.
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