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Recently published articles about Difficult to Treat Depression

JCP
Effects of Low-Dose Ketamine Infusion on Hopelessness and Suicidal Thoughts
Original Research

July 8, 2024

A single infusion of low-dose ketamine resulted in a brief (~4 hour) yet significant reduction in hopelessness.
Wei-Chen Lin, Mu-Hong Chen, Tung-Ping Su, et al
JCP
Immune Targeted Therapies for Depression: Antidepressant Effects of Monoclonal Antibodies
Narrative Review

June 24, 2024

Immune dysregulation may contribute to treatment resistance in depression. Monoclonal antibodies have shown promise in treating depression when used for inflammatory disorders and may offer new hope for patients...
Mina M. Rizk, Lindsay Bolton, Flurin Cathomas, et al
JCP
Barriers to Esketamine Nasal Spray Use in Treatment-Resistant Depression
Original Research

May 6, 2024

Potential barriers to treatment with esketamine nasal spray include travel distance, insurance, low socioeconomic status, and minority communities.
Kruti Joshi, Joshua N. Liberman, Purva Parab, et al
Study Reveals Stronger Genetic Link to TRD
news

April 9, 2024

A new study has revealed a connection between a family history of TRD and increased risks of suicide mortality and resistance to treatment.
PCC
Transcranial Magnetic Stimulation in Primary Care
Rounds in the General Hospital

March 12, 2024

TMS is a safe, effective, and well-tolerated noninvasive neurotherapeutic procedure that utilizes a strong electromagnetic field to change brain activity in a targeted fashion to treat a variety of...
Mahdi Razafsha, Tracy A. Barbour, Amit Chopra, et al
PCC
Intravenous Ketamine vs Intranasal Esketamine for TRD
Letter to the Editor

February 13, 2024

Dr Mansuri and colleagues compare the pros and cons of IV ketamine and intranasal esketamine for treatment-resistant depression.
Zeeshan Mansuri, Bhumika Shah, Garima Yadav, et al
PCC
Long-Term Preservation TMS for MDD
Case Report

December 14, 2023

Two cases provide a unique look at how remission of depression can be maintained over a long duration using scheduled treatments of preservation transcranial magnetic stimulation with progressively increasing...
Zeeshan Faruqui, Irakli Mania, Mariam Gigilashvili, et al
JCP
Predictors and Risk Factors of Treatment-Resistant Depression
Systematic Review

November 13, 2023

Early identification of individuals with major depressive disorder who are likely to develop treatment-resistant depression (TRD) is needed. This study reviewed the literature to identify and categorize the predictors...
Shane J. O’Connor, Nilay Hewitt, Joanna Kuc, et al
PCC
Adjunct Minocycline in Treatment-Resistant Depression
Systematic Review

September 14, 2023

Minocycline has shown inconsistent immunomodulator clinical effect in treatment-resistant depression.
Wisam Al Jumaili, Darshini Vora, Chintan Trivedi, et al
news

August 31, 2023

Dr. Christina Cusin reviews ketamine for depression and suicidality, including patient suitability, administration, treatment duration, and drug compatibility.
Antidepressant-Resistant Depression Biotype Identified in 27% of Study Patients
news

August 7, 2023

Study reveals unique cognitive biotype in 27 percent of depression patients, suggesting the potential for tailored therapy.
PCC
Management of Treatment-Resistant Depression in Primary Care
Rounds in the General Hospital

July 25, 2023

Novel and innovative clinical care pathways that integrate specialist care need to be implemented to address the burden of treatment-resistant depression in primary care.
Amit Chopra, James Luccarelli, Jonah N. Cohen, et al

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