Original Research J Clin Psychiatry September 2026

The Role of Chronic Anhedonia in the Relationship Between Treatment-Resistant Depression and Suicidality

JCP 2026;87(3):10.4088/JCP.25m16189

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. JCP 2026;87(3):10.4088/JCP.25m16189 Clinical Summary Patients with treatment-resistant depression often remain symptomatic despite multiple medication trials, and many present with ongoing suicide risk that is difficult to stratify in routine care. This study highlights a practical signal clinicians can assess quickly: whether anhedonia has been present both historically and currently, not just in the past 2 weeks. FAQ What did this study find about chronic anhedonia and suicidality in treatment-resistant depression? 10 questions
Key Takeaways In this specialty mood and anxiety sample, 97 of 160 participants met criteria for treatment-resistant depression, underscoring how commonly antidepressant nonresponse presents in referral populations with a history of major depressive episodes. 6 takeaways Clinical Guide How can clinicians identify chronic anhedonia in patients with treatment-resistant depression to inform suicide risk assessment? 6 steps
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