Original Research

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JCP
Original Research

December 28, 2016

Cortical thinning, identified during prodromal Alzheimer's disease, is a "candidate" biomarker used in clinical therapy trials. This study looked at change in cortical thickness after 1 year of donepezil...
Enrica Cavedo, Bruno Dubois, Olivier Colliot, et al
JCP
Original Research

December 28, 2016

Twenty US veterans kill themselves every day. What more can be done to stop this self-slaughter? Dialectical behavior therapy (DBT), which combines behavioral intervention with cognitive techniques of mindfulness,...
Marianne Goodman, David Banthin, Nicholas J. Blair, et al
JCP
Original Research

December 28, 2016

Understand the association between depression and levels of C-reactive protein (CRP) and fractional exhaled nitric oxide (FeNO).
M. Soledad Cepeda, Paul Stang, Rupa Makadia
JCP
Original Research

December 28, 2016

Cognitive difficulties may be overlooked in treating patients with bipolar or unipolar depression, but 20% of patients report such symptoms. The authors of this article reanalyzed data from 2...
Kamilla Woznica Miskowiak, A. John Rush, Jr, Thomas A. Gerds, et al
JCP
Original Research

December 28, 2016

Carlos Blanco, Melanie M. Wall, Martin A. Lindquist, et al
JCP
Original Research

December 28, 2016

What's the next step when a patient doesn' t respond to an antipsychotic? Should you augment, switch medications, wait and see, or raise the dose? Read this study in...
Antony Loebel, Robert Silva, Robert Goldman, et al
JCP
Original Research

December 28, 2016

Antipsychotics such as risperidone and aripiprazole are efficacious for controlling behavioral symptoms in children with intellectual disability or autism spectrum disorder, but they are also associated with adverse reactions...
Marco Pozzi, Simone Pisano, Silvana Bertella, et al
JCP
Original Research

December 28, 2016

Sigal Zilcha-Mano, John R. Keefe, Harold Chui, et al
JCP
Original Research

December 28, 2016

When your 18- to 26-year-old patients respond poorly to the antipsychotic prescribed for their first episode of psychosis, what else can you try? In this RCT, taurine, which acts...
Colin P. O'Donnell, Kelly A. Allott, Brendan P. Murphy, et al
JCP
Original Research

December 28, 2016

Are rates of depression and bipolar disorder going up? If so, why? To answer these questions, this Danish study looked at trends in diagnosed affective disorders over the last...
Christina Mohr Jensen, Hans-Christoph Steinhausen
JCP
Original Research

December 28, 2016

Read a study whether the Montgomery-Asberg Depression Rating Scale (MADRS) can assess the rapid onset of the antidepressant effect of a treatment in patients.
Kristen M. Johnson, Jacob M. Devine, Kai Fai Ho, et al
JCP
Original Research

December 28, 2016

The worries that characterize generalized anxiety disorder are so pervasive and excessive that they distort cognition and create a considerable burden of illness. See what the authors of this...
Suresh Durgam, Carl Gommoll, Giovanna Forero, et al
JCP
Original Research

December 6, 2016

Patients with insomnia and disrupted sleep are at increased risk of suicide. Check out this article to see if researchers found a link between antisuicidal response to ketamine and...
Jennifer L. Vande Voort, Elizabeth D. Ballard, David A. Luckenbaugh, et al
JCP
Original Research

November 23, 2016

Several antipsychotics have shown efficacy for schizophrenia in controlled settings, but how effective are they in the long-term treatment of individuals in community settings? Learn how 7 antipsychotics compared...
Chen Zhang, Mei-Juan Chen, Guo-Jun Wu, et al
JCP
Original Research

November 23, 2016

As many as 25% of patients with first-episode psychosis experience nonremission or treatment resistance. Read this article to see whether initiating clozapine earlier in treatment can lead to better...
Charmaine Tang, Mythily Subramaniam, Boon Tat Ng, et al
JCP
Original Research

November 23, 2016

Is clozapine safe for patients with benign neutropenia? Many patients with lower than normal absolute neutrophil count do not qualify for clozapine therapy or are at risk of having...
Charles M. Richardson, Erica A. Davis, Gopal R. Vyas, et al
JCP
Original Research

November 23, 2016

Aripiprazole lauroxil, a long-acting injectable antipsychotic, demonstrated safety and efficacy in treating schizophrenia symptoms in a recent RCT. But how does it stack up against other antipsychotics in terms...
Henry A. Nasrallah, John W. Newcomer, Robert Risinger, et al
JCP
Original Research

November 23, 2016

Knowing that patients with posttraumatic stress disorder and substance use disorder share impaired prefrontal cortex regulation, particularly at glutamate synapses in the nucleus accumbens, the authors conducted this first-ever...
Sudie E. Back, Jenna L. McCauley, Kristina J. Korte, et al
JCP
Original Research

November 23, 2016

Some have argued that changes to the diagnostic criteria for PTSD in the DSM-5 would increase rates of comorbidity between PTSD and other psychiatric disorders. Find out whether that...
Blair E. Wisco, Brian P. Marx, Mark W. Miller, et al
JCP
Original Research

October 26, 2016

How frequently do soldiers seek mental health treatment after being deployed? What types of care do they require? A study by Madsen et al looked at mental health service...
Trine Madsen, Søren Bo Andersen, Karen-Inge Karstoft
JCP
Original Research

October 26, 2016

Read this article to learn whether age of onset of bipolar disorder or psychiatric illness is due to demographics or family psychiatric history.
Robert M. Post, Lori L. Altshuler, Ralph Kupka, et al
JCP
Original Research

October 26, 2016

If a patient with depression continues to have problems sleeping even after their depression is treated, what is the best course of action? In this RCT involving patients already...
Rachel Manber, Daniel J. Buysse, Jack Edinger, et al
JCP
Original Research

October 26, 2016

Characterizing the role of inflammation in depression is an important part of identifying potential targets for intervention. Zheng and colleagues assessed plasma dipeptidyl peptidase-4 activity, inflammatory markers, and neuropeptide...
Tianpeng Zheng, Yihong Liu, Shenghua Qin, et al
JCP
Original Research

October 26, 2016

Use of psychiatric emergency departments in the United States has risen substantially in recent decades. Read this article to see how well a clinical tool performed in triaging emergency...
Kevin D. Shield, Paul Kurdyak, Paul A. Shuper, et al

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