Systematic Review

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PCC
Ketogenic Diet Therapies in Pediatric Epilepsy
Systematic Review

June 25, 2024

In this systematic review, the authors evaluated the effects of a ketogenic diet on epilepsy in children and adolescents.
Dilshad Parveen, Vidisha Jain, Dhivya Kannan, et al
PCC
Obsessive-Compulsive Symptoms in Dementia
Systematic Review

June 18, 2024

The authors assess the literature on neurobiological mechanisms of obsessive-compulsive symptoms in dementia patients to shed light on the similarities and differences between these symptoms in dementia and in...
Filipe P. Martinho, Tiago F. Ferreira, Daniela Magalhães, et al
PCC
Impact of Theta Burst Stimulation on MS
Systematic Review

April 18, 2024

Theta burst stimulation interventions may hold promise in addressing specific multiple sclerosis symptoms, notably fatigue and spasticity.
David F. Lo, Meejan Palhang, Ahmed Gawash, et al
PCC
Therapist-Guided Versus Self-Guided CBT
Systematic Review

March 21, 2024

Results were positive for the use of internet-based cognitive-behavioral therapy and encouraging for new methods of guided therapy and the inclusion of technology.
Luísa Pelucio, Laiana A. Quagliato, Antonio Egídio Nardi
JCP
Systematic Review of the Effects of Cannabis and Cannabinoids in PTSD Symptoms and Symptom Clusters
Systematic Review

February 14, 2024

This review of 14 studies did not find major benefits of cannabinoids in improving overall PTSD symptoms, although some benefits in cluster B and E symptoms were seen. Risks...
Justyne D. Rodas, Tony P. George, Ahmed N. Hassan
PCC
Psychedelic Microdosing and Mental Health
Systematic Review

January 16, 2024

There is a growing body of evidence suggesting a positive correlation between psychedelic microdosing and improved mental well-being.
David F. Lo, Hasan Zia, Pranetha Rajkumar, et al
PCC
Efficacy and Safety of Loxapine in Acute Agitation
Systematic Review

December 19, 2023

Loxapine was found to be more effective and faster regarding acute agitation control and was well-tolerated, with mildly or moderately severe adverse effects.
Camille Lebel, Francky Teddy Endomba, Guillaume Chabridon, et al
JCP
Predictors and Risk Factors of Treatment-Resistant Depression
Systematic Review

November 13, 2023

Early identification of individuals with major depressive disorder who are likely to develop treatment-resistant depression (TRD) is needed. This study reviewed the literature to identify and categorize the predictors...
Shane J. O’Connor, Nilay Hewitt, Joanna Kuc, et al
PCC
Psychiatric Observation Unit Impact on ED Boarding
Systematic Review

November 7, 2023

Psychiatric observation units are mainly described within large urban general or academic hospital centers. Patients present predominantly with acute mental health crises or suicidality and are typically treated < 72...
Alastair W. Magarey, Jianfeng Weng, Jeffrey C. L. Looi, et al
PCC
Body Dysmorphia, Steroid Use, and Mental Health
Systematic Review

October 24, 2023

Steroid use is associated with many detrimental effects on mental health, including a higher risk of developing symptoms of psychosis, depression, anxiety, and aggression.
Ahmed Gawash, Hasan Zia, Usmaan Al-Shehab, et al
PCC
Cognition in Schizophrenia
Systematic Review

October 12, 2023

This systematic review showed specific cognitive functioning in individuals diagnosed with schizophrenia, highlighting lower than average performance compared to healthy controls regarding executive cognitive functions such as information processing,...
Tatiane Bombassaro, Carolina Gomes Carrilho, Clayton Peixoto, et al
PCC
Adjunct Minocycline in Treatment-Resistant Depression
Systematic Review

September 14, 2023

Minocycline has shown inconsistent immunomodulator clinical effect in treatment-resistant depression.
Wisam Al Jumaili, Darshini Vora, Chintan Trivedi, et al
JCP
Therapeutic Reference Range for Olanzapine
Systematic Review

July 19, 2023

A therapeutic reference range of 20–40 ng/mL for oral and long-acting injectable olanzapine yields optimal treatment effects in schizophrenia spectrum disorders. Dose reduction is not needed above 40 ng/mL...
Katja Wesner, Christoph Hiemke, Niels Bergemann, et al
JCP
GnRH Analogs in Premenstrual Dysphoric Disorder: Review and Practical Guideline
Systematic Review

June 21, 2023

This guideline provides screening tools, patient and provider handouts, and in-depth analysis of GnRH analogs and hormonal addback paradigms in PMDD.
Melissa Wagner-Schuman, Alyssa Kania, Jordan C. Barone, et al
PCC
Internet Addiction and Mental Disorders in Medical Students
Systematic Review

June 6, 2023

Early identification and management of internet addiction is needed, as it results in unfavorable mental health outcomes and impacts the work performance of medical students and physicians.
Isabela Azeredo Melca, Eduardo Kunzel Teixeira, Antonio Egídio Nardi, et al
PCC
Seasonality in Mood Disorders and Suicide Risk
Systematic Review

May 25, 2023

There is a summer peak for many aspects of mental health activity, particularly in terms of acute hospital utilization and suicidality.
David F. Della, Stephen Allison, Niranjan Bidargaddi, et al
PCC
Neurobiological Correlates of Psilocybin Response in MDD
Systematic Review

May 23, 2023

Transient functional brain changes with psilocybin therapy resemble the “brain reset” phenomenon and may serve as the putative predictors of psilocybin antidepressant response.
Saleha Qasim, Zaofashan Zaheer, Muhammad Youshay Jawad, et al
JCP
Control Conditions in Randomized Trials of Psychedelics: An ACTTION Systematic Review
Systematic Review

May 10, 2023

Randomized trials of psychedelics underutilize blind assessment, active drug controls, and testing psychological support against minimal-support conditions—elements that would improve quality or provide important information.
Sandeep M. Nayak, Melissa K. Bradley, Bethea A. Kleykamp, et al
JCP
Resilience in Bipolar Disorder
Systematic Review

February 22, 2023

Bipolar disorder patients with greater resilience had less severe symptoms, more positive attitudes toward medication treatment, and better social support and functioning.
Min Kai Chan, Qian Hui Chew, Kang Sim
PCC
Substance Withdrawal and Takotsubo Cardiomyopathy
Systematic Review

February 21, 2023

Takotsubo cardiomyopathy should be suspected when patients develop atypical symptoms in the setting of substance withdrawal, including tachycardia, blood pressure changes, chest pain, dyspnea, and altered mental status.
Danielle K. Back, An H. Bui, Saeed Ahmed, et al
PCC
Impact of Paternal Depression on Children
Systematic Review

February 7, 2023

An association exists between paternal mental health and depressive symptoms and neurodevelopmental disorders in infants and children.
Sahar Ashraf, Kaushal Shah, Ramu Vadukapuram, et al
JCP
Managing Obstructive Sleep Apnea in Psychiatric Practice
Systematic Review

January 23, 2023

As shown in this review, OSA may be a risk factor for the development of psychiatric conditions, as well as suicidal ideation and attempts.
Ruth M. Benca, Andrew Krystal, Craig Chepke, et al
PCC
Opioid Use Disorder and Its Treatment in the Elderly
Systematic Review

January 10, 2023

OUD may be particularly problematic in the elderly due to age-related pain syndromes and comorbidities that increase the risk of side effects, overdose, and death. This review assessed the...
Jaya Sri Konakanchi, Roopa Sethi
PCC
Impact of Treating Depression on Associated Comorbidities
Systematic Review

January 3, 2023

Effective treatment of MDD may lead to a reduction in the severity of certain serious comorbidities. This review highlights the importance of appropriate and timely treatment of MDD.
Alix M. Arnaud, Teri S. Brister, Ken Duckworth, et al

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