The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

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Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

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JCP
Olanzapine and Mirtazapine for Cancer-Related Anorexia
Clinical and Practical Psychopharmacology

August 21, 2024

Dr Andrade discusses two RCTs that investigated the utility of olanzapine and mirtazapine in addressing appetite loss in cancer patients.
Chittaranjan Andrade
JCP
Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
Christoph U. Correll, Pin Xiang, Kaushik Sarikonda, et al
JCP
Functional Unblinding in Pivotal Studies and the Future of Psychedelic Medicine
Commentary

August 21, 2024

Dr Rosenbaum comments on the challenge of evaluating trials of treatments whose effects are unmistakable, and how this dilemma may be addressed.
Jerrold F. Rosenbaum

Vol 85 • 2024 • Number 3

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Editorial

Focus on Women’s Mental Health: Twenty Years and Counting

Original Research

Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants

Commentary

Can Our Collective Experiences As Clinicians Improve Mental Health Care?

Original Research

Prescription Opioid Use Disorder in US Adults Reporting Prescription Opioid Use

Original Research

Symptomatic Disorders Comorbid with Borderline Personality Disorder Over Time

Original Research

Aripiprazole Lauroxil Initiation Regimens
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Focus on Psychosis Focus on Geriatric Psychiatry Focus on Women's Mental Health Focus on Suicide Early Career Psychiatrists Focus on Psychotherapy Childhood and Adolescent Mental Health

Original Research

JCP
Prevalence and Course of Unwanted, Intrusive Thoughts of Infant-Related Harm
Original Research

August 14, 2024

Although intrusive thoughts of accidental and intentional infant harm are a common and normative postpartum experience, they cause distress for many new mothers. Clinically significant symptoms that remain by…
Fanie Collardeau, Olivia L. U. Anglin, Arianne Y. K. Albert, et al
JCP
Differentiation Across Bipolar Disorder and MDD by Whole-Night Polysomnographic Findings
Original Research

August 14, 2024

PSG-measured sleep abnormalities, such as reduced REM latency, may be a diagnostic differentiating factor between MDD and bipolar disorder.
Meihong Xiu, Wenxin Li, Yu Lan, et al
JCP
Predictive Validity of Early Post-Injury CAPS-5 Score for Later PTSD Diagnosis
Original Research

August 5, 2024

A CAPS-5 score of ≥15 provided good predictive accuracy for subsequent PTSD development in the general injured population.
Jae-Min Kim, Ju-Wan Kim, Hee-Ju Kang, et al

Review Articles

JCP
Cognitive Effects of ECT in Schizophrenia: A Review
Review Article

June 5, 2024

ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
Sophie R. Vaccarino, Anthony L. Vaccarino
JCP
Interpersonal Psychotherapy for PTSD: A Critical Review
Review Article

May 29, 2024

This critical review will give clinicians confidence in considering IPT as an alternative to exposure treatments for posttraumatic stress disorder.
John C. Markowitz
JCP
Omega-3 PUFA Supplements for ADHD
Meta-Analysis

August 30, 2023

Although omega-3 polyunsaturated fatty acids (PUFAs) may not improve core symptoms of attention-deficit/hyperactivity disorder, longer-term PUFA supplementation may have potential benefits.
Ting-Hui Liu, Jheng-Yan Wu, Po-Yu Huang, et al
JCP
Mechanisms of Treatment of Bipolar Disorder and Borderline Personality Disorder: Brain Imaging Research
Meta-Analysis

March 27, 2023

Different brain regions were changed with psychotherapy versus medication. The findings may help with predicting treatment efficacy and identifying treatment biomarkers in these disorders.
Jingyi Luo, Meng Liang, Pengcheng Yi, et al
JCP
Antipsychotic Dose and Weight Gain
Meta-Analysis

February 8, 2023

Although effects on weight gain have been explored for several antipsychotics, the role of dose in producing these effects has not been widely studied. This meta-analysis examined the association…
Michel Sabé, Konstantinos Pallis, Marco Solmi, et al
JCP
Rapidity of Improvement With Intranasal Esketamine for MDD
Meta-Analysis

December 12, 2022

This meta-analysis found that augmenting antidepressants with intranasal esketamine vs placebo was more effective in reducing depression severity at 24 hours and study endpoint.
Rebecca S. Hock, Anna Feeney, Nadia Iovieno, et al

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JCP
Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia
Narrative Review

August 19, 2024

While the pathophysiology of schizophrenia is complex, treatments with novel pharmacological actions that target these systems are of interest as adjunctive treatment for schizophrenia.
Bruce J. Kinon, Stefan Leucht, Carol Tamminga, et al
JCP
Sleep Disturbances and Perceived Stress in Substance Use Disorder Treatment
Original Research

July 31, 2024

Higher stress was associated with more severe insomnia, and vice versa, both at treatment intake and over the course of treatment, regardless of primary substance.
Martin Hochheimer, Jennifer D. Ellis, Brion Maher, et al
JCP
Aerobic Exercise for Erectile Dysfunction
Clinical and Practical Psychopharmacology

July 29, 2024

Dr Andrade discusses a recent meta-analysis indicating benefits of aerobic exercise in the primary prevention of erectile dysfunction.
Chittaranjan Andrade
JCP
Underdiagnosis, Undertreatment, and Noncompliance With Treatment in People Who Died by Suicide
Original Research

July 10, 2024

Depression was diagnosed prior to death in 18.6% of people with a major depressive episode who died by suicide. Antidepressants were prescribed in 21.5% of these individuals, but only…
Belén S. Martín-Moreno, Julio Guija, Mario Blanco, et al
JCP
Effects of Low-Dose Ketamine Infusion on Hopelessness and Suicidal Thoughts
Original Research

July 8, 2024

A single infusion of low-dose ketamine resulted in a brief (~4 hour) yet significant reduction in hopelessness.
Wei-Chen Lin, Mu-Hong Chen, Tung-Ping Su, et al
JCP
Epilepsy, Antiepileptic Drugs, and Adverse Pregnancy Outcomes, 2: Major Congenital Malformations
Clinical and Practical Psychopharmacology

July 3, 2024

This article reviews evidence from a large registry, a population-based study, and a meta-analysis on the risks of major congenital malformation with untreated epilepsy and with exposure to antiepileptic…
Chittaranjan Andrade
JCP
Borderline Personality Disorder and Eating Disorders: The Role of Emotion Regulation
Original Research

July 3, 2024

Deficits in emotion regulation significantly predicted borderline personality disorder (BPD). Although eating disorders were not significantly predicted by emotion regulation deficits, they did predict BPD diagnoses.
Samantha C. Dashineau, Caroline E. Balling, Susan C. South, et al
JCP
Metabolic Syndrome in Offspring of Bipolar Parents
Original Research

July 1, 2024

In offspring of parents with bipolar disorder, lower socioeconomic status and personal history of mood disorders were associated with greater risk of metabolic syndrome and its components.
Nidhi P. Kulkarni, Mikaela K. Dimick, Kody G. Kennedy, et al
JCP
Suicidal Status, Inflammation, and Resting-State Activity in MDD
Original Research

June 26, 2024

Resting-state activity of the VLPFC was altered in suicide attempters, possibly contributing to language impairment and poor decision-making and cognitive control.
Emilie Olié, Guillaume Clain, Manon Malestroit, et al
JCP
Mental Health Assessments for Fetal Interventions
Letter to the Editor

June 24, 2024

The authors offer guidance and raise awareness about the intersection of maternal mental health and fetal interventions.
Sindhura Vangala, Roy Williams Jr., Cara M. Buskmiller, et al
JCP
Immune Targeted Therapies for Depression: Antidepressant Effects of Monoclonal Antibodies
Narrative Review

June 24, 2024

Immune dysregulation may contribute to treatment resistance in depression. Monoclonal antibodies have shown promise in treating depression when used for inflammatory disorders and may offer new hope for patients…
Mina M. Rizk, Lindsay Bolton, Flurin Cathomas, et al
JCP
Depression, Rumination, and Suicide Attempts in Adolescents With Mood Disorders: Sex Differences
Original Research

June 19, 2024

The authors found that in male adolescents, suicide attempts are mostly influenced by depressive symptoms. In female adolescents, depressive symptoms not only directly increase the risk of suicide attempts,…
Dianying Liu, Gang Lei, Dian Li, et al

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