An older man with short white hair, glasses, and a slight smile wears a dark suit jacket and light blue shirt, posing in front of a dark, plain background.

A. John Rush, MD

Duke-NUS Medical School, Singapore

  • 96Articles
  • 335.5KReads
  • 1996–2026Active
  • 359Collaborators
  • 6.5KCitations

About

A. John Rush, MD, is affiliated with Duke-NUS Medical School, Singapore, and Curbstone Consultant LLC in Dallas, Texas. With a publication record spanning from 1996 to 2026, Rush has contributed 95 articles on topics including depression, bipolar disorder, schizophrenia, suicide, child and adolescent psychiatry, and electroconvulsive therapy. Frequent collaborators include Madhukar H. Trivedi, Maurizio Fava, Stephen R. Wisniewski, Michael E. Thase, and Andrew A. Nierenberg.

Publications

JCP
When Do Physical Symptoms After Antidepressant Cessation Reflect Pharmacodynamic versus Non-pharmacodynamic Clinical Phenomena?
ASCP Corner

When Do Physical Symptoms After Antidepressant Cessation Reflect Pharmacodynamic versus Non-pharmacodynamic Clinical Phenomena?

August 6, 2026

Focuses on descriptive symptom phenomenology and strategies to minimize discomfort during antidepressant cessation, with possible explanations for unusual, delayed, or protracted symptoms in patients for whom non-pharmacodynamic features may...
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JCP
Impact of VNS on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report
Original Research ▶ Video

Impact of VNS on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report

July 8, 2026

Findings suggest that active VNS reduces suicidal ideation (SI) and potentially induces SI remission among participants with chronic TRD and baseline SI.
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JCP
Bridging Research and Reality in Mental Health Care with A. John Rush, MD
Podcast

Bridging Research and Reality in Mental Health Care with A. John Rush, MD

April 7, 2026

A. John Rush, MD, explores how measurement-based care and pragmatic trial design can bridge the gap between psychiatric research and clinical practice.
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JCP
Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
Original Research

Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

July 14, 2025

History of ECT use (lifetime and current episode) or TMS use (current episode) was prognostic of poorer outcomes across the total sample and superior benefit from active versus sham...
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JCP
Can Our Collective Experiences As Clinicians Improve Mental Health Care?
Commentary

Can Our Collective Experiences As Clinicians Improve Mental Health Care?

July 17, 2024

Drs Rush and Tramontin discuss how simple outcomes, often patient reported, could facilitate evidence-based decision making by clinicians, administrators, and payors and provide the foundation for a learning health...
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JCP
A Comparison of 3 Scales for Measuring Adolescent Depression
Original Research

A Comparison of 3 Scales for Measuring Adolescent Depression

December 18, 2023

Three patient-reported outcomes—Patient Health Questionnaire for Adolescents, Quick Inventory of Depressive Symptomatology–Self-Report, and Very Quick Inventory of Depressive Symptomatology–Self-Report—can assess depressive symptom severity and change over time. Scores on...
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PCC
New-Onset Psychosis After COVID-19 Vaccine
Case Report

New-Onset Psychosis After COVID-19 Vaccine

November 15, 2022

A 45-year-old woman with no psychiatric history developed psychosis after receiving the COVID-19 vaccine. This report highlights that history of recent vaccine administration as a potential etiology deserves consideration...
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JCP
In Memoriam: Jan Fawcett, MD
In Memoriam

In Memoriam: Jan Fawcett, MD

July 11, 2022

A. John Rush and Steven D. Hollon reflect on Fawcett’s life and his contributions to the field, especially in the areas of treatment-resistant depression and suicide.
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JCP
Toward A Definition Of “No Meaningful Benefit” From Antidepressant Treatment
Original Research

Toward A Definition Of “No Meaningful Benefit” From Antidepressant Treatment

June 27, 2022

The aim of this study was to develop and validate a categorical definition of “no meaningful benefit” from antidepressant treatment by equating percent change in scores on 3 common...
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PCC
Case Report

HHV-6 and Schizophrenia

January 6, 2022

Primary psychosis is the result of an underlying psychiatric disorder, while secondary psychosis is due to a medical cause. Here, the authors present a case of HHV-6 infection with...
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JCP
Commentary

Therapeutic Inertia

November 2, 2021

This commentary discusses therapeutic inertia--failure to (1) establish an optimal treatment dose to reach a desired outcome and (2) change treatment when a first treatment does not produce remission—in...
PCC
Case Report

High Output Ileostomy Secondary to Subtherapeutic Valproic Acid

June 24, 2021

Diarrhea is a common side effect of divalproex sodium. Here, the authors present a geriatric case of divalproex sodium causing a high output despite numerous pharmacologic interventions.
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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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