Addition of Lamotrigine to Clozapine in Inpatients With Chronic Psychosis

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Sir: Two studies have reported a substantial reductionof symptoms when the anticonvulsant drug lamotrigine wasadded to clozapine in patients with treatment-resistant schizophrenia.^1,2 We report on 6 inpatients with persistent and severepsychotic symptoms who were treated for 24 weeks with a combinationof lamotrigine and clozapine.

Method. The study, which was conducted between December2000 and August 2002, was approved by an independentmedical ethics committee, and all patients gave informed consent.