Addition of Risperidone to Clozapine Therapy in Chronically Psychotic Inpatients

Letter to the Editor

Sir: Patients with schizophrenia who remain severely psychotic despite several courses of treatment with classical antipsychotics and clozapine constitute a major problem in clinical practice. One 4-week open trial, reported by Henderson and Goff, showed that augmentation of clozapine with risperidone produced at least a 20% reduction on the Brief Psychiatric Rating Scale (BPRS) in 10 of 12 schizophrenic outpatients with persistent psychotic symptoms.