AMPA Blockade May Be the Mechanism Underlying the Efficacy of Topiramate in PTSD

Sir: We read with great interest the report of Berlant and van Kammen on topiramate in posttraumatic stress disorder (PTSD). They report particularly on suppression of nightmares and flashbacks and propose the suppression of kindling mechanisms as underlying topiramate’s efficacy for these symptoms. We would propose a further possible mechanism, which has not been considered by the authors.