Antiadrenergic Treatment of Antidepressant-Induced Excessive Sweating in 3 Patients

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Sir: Excessive sweating is a common adverse effect of many antidepressant medications. Its prevalence with selective serotonin reuptake inhibitors (SSRIs) is between 7% and 19% depending on the drug.¹ In a meta-analysis² of clinical trials pooled across SSRIs, the rate of sweating as an adverse effect was 10%.