Aripiprazole Augmentation of Clomipramine-Refractory Obsessive-Compulsive Disorder

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Sir: Antipsychotic augmentation strategy is relevant in obsessive-compulsive disorder (OCD), as half of patients fail to respond to an initial adequate trial of serotonin reuptake inhibitors.¹ Aripiprazole is an antipsychotic drug that acts as a partial agonist at dopamine D₂ and serotonin 5-HT_1A receptors. The drug is also a serotonin 5-HT_2A receptor antagonist that might be of therapeutic value in OCD, as suggested by an open-label aripiprazole monotherapy study.²