Bupropion-Amantadine-Associated Neurotoxicity

Letter to the Editor

Sir: The antidepressant drug bupropion is a substituted chloropropiophenone with a structure reminiscent of stimulant and anorectic drugs such as diethylpropion. It exerts both a stimulant profile, as shown by increases in motor activity, and an antidepressant profile. Some data show that bupropion increases dopamine concentration in the mesolimbic system involved in the neural circuitry of reward.