A Case of Olanzapine-Induced Gestational Diabetes Mellitus in the Absence of Weight Gain

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Sir: Second-generation antipsychotics have been implicated in the development of obesity, diabetes mellitus, and insulin resistance. Pregnancy increases the risk for insulin resistance, sometimes resulting in gestational diabetes mellitus. We describe a case of a woman with bipolar disorder who developed gestational diabetes in the absence of significant weight gain while treated with olanzapine during 2 pregnancies.’ ‹