Letter to the Editor
Sir: Sodium oxybate is increasingly being used off-labelto treat the fibromyalgia syndrome defined by pain, fatigue,nonrefreshing sleep, and fluency loss. This compound has acomplicated mechanism of action with agonist binding on?-aminobutyric acid (GABA)-B receptor, agonist binding on the?-hydroxybutyrate (GHB) receptor, and possible stoichiometricsignaling effects as an intermediary in GABA and glutamatemetabolism. Its clinical effect is a profound increase in the durationof stage III and IV slow wave sleep. This case describesa profound effect of oxybate on bipolar disorder and tardivedyskinesia presenting jointly with fibromyalgia.
Author Affiliations
Save
Share
Cite
