Two Cases of Acneiform Eruption Associated With Lamotrigine

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Sir: Lamotrigine (3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4- triazine) is an anticonvulsant commonly used for the treatment of epilepsy. More recently, it has also become widely used in psychiatry for the treatment of bipolar disorder.¹ It is generally well tolerated. Benign skin reactions such as morbilliform, urticarial, or maculopapular rash occur in approximately 10% of patients.²