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The Clinical Manual of Addiction Psychopharmacology, edited by Henry R. Kranzler, M.D., and Domenic A. Ciraulo, M.D., provides a comprehensive and detailed review of the pharmacologic mechanisms of most commonly used and abused drugs as well as the psychotherapeutic approaches to treat the abuse of these drugs and their dependence properties. This book is drafted and designed with a clinical emphasis; obviously, the intent is for the book to be an ideal manual for busy health and mental health practitioners, psychologists, social workers, and other mental health professionals at large, as well as for psychiatric educators and students. In my opinion, this objective was, indeed, met.