Clozapine in the Treatment of Hypomania With Neurosyphilis

Letter to the Editor

Sir: Clozapine is effective for various psychiatric conditions, including psychosis in neurologic disorders. Neurosyphilis is infrequent today with early treatment, but its psychiatric complications ranging from personality change to psychosis and dementia have been described. I report a patient with hypomania and initially undetected neurosyphilis, who could not be stabilized with neuroleptics and finally responded to clozapine.