Combination of Donepezil and Gabapentin for Behavioral Disorders in Alzheimer's Disease

Letter to the Editor

Sir: Behavioral symptoms are very frequent in patients with Alzheimer’s disease, and management of these symptoms is a primary goal of therapy. Several drugs may be used with benefit, including atypical neuroleptics, selective serotonin reuptake inhibitors, anticonvulsants, tacrine, and the newer acetylcholinesterase inhibitors such as donepezil, recently indicated for the symptomatic treatment of Alzheimer’s disease. Indeed, there are conflicting reports in the literature about the action of donepezil in behavioral disorders associated with Alzheimer’s disease, with some authors reporting a benefit and others reporting a worsening of the symptoms.