Comments on a Randomized, Double-Blind Comparison of Sertraline and Placebo for Posttraumatic Stress Disorder in a Department of Veterans Affairs Setting

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Sir: Selective serotonin reuptake inhibitor antidepressantsare first-line pharmacologic treatments of posttraumatic stressdisorder (PTSD).^1,2 Robust effects have been seen in previouslarge studies of sertraline in civilian populations.^3,4 The recent(May 2007) study by Friedman and colleagues5 failed to findevidence of efficacy of sertraline in a veteran population, despitea comprehensive analysis of potential moderator variables.’ ‹