Concluding Remarks

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In closing, I would like to review the rationale for developing new atypical agents forantipsychotic pharmacotherapy and to summarize information presented at this symposium about the innovative drug olanzapine.Numerous reviews of the literature suggest that the typical antipsychotic medications arefar from optimal in treating psychosis. For example, Goff and Shader1 reported that more thanhalf of patients receiving such a drug do not respond optimally.