The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

The Journal of
Clinical Psychiatry

Volume 85 • 2024 • Number 3

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Archive Volume 85 Current Issue

Commentary

JCP
Learning by Doing: Can Our Collective Experiences as Clinicians Improve Mental Health Care?
Commentary

July 17, 2024

Drs Rush and Tramontin discuss how simple outcomes, often patient reported, could facilitate evidence-based decision making by clinicians, administrators, and payors and provide the foundation for a learning health...
A. John Rush, MD; Tony Tramontin, PhD
JCP
Commentary

August 26, 2024

Dr Freeman discusses a recent study by Pacilio et al that characterized real world practices around ketamine treatment and pregnancy testing, consent processes, and contraception use. She emphasizes the...
Marlene P. Freeman, MD
JCP
Functional Unblinding in Pivotal Studies and the Future of Psychedelic Medicine
Commentary

August 21, 2024

Dr Rosenbaum comments on the challenge of evaluating trials of treatments whose effects are unmistakable, and how this dilemma may be addressed.
Jerrold F. Rosenbaum, MD
JCP
Extreme Dysphoria of Pregnancy: A Distinct Syndrome Warranting Attention?
Commentary

June 10, 2024

Dr Freeman discusses the understudied phenomenon of pregnancy-related extreme dysphoria or depression, distinct from typical major depressive episodes. Three illustrative case vignettes are presented.
Marlene P. Freeman, MD

Case Report

JCP
Case Report

August 26, 2024

A man with AUD achieves sobriety on treatment with an SSRI and naltrexone, but then stops taking the SSRI to participate in a psilocybin “ceremony.” What factors contributed to...
Mark A. Frye, MD; Balwinder Singh, MD, MS; Scott A. Breitinger, MD; Tyler S. Oesterle, MD, MPH

Clinical and Practical Psychopharmacology

JCP
Therapeutic Effects, Side Effects, and Adverse Effects of Neuropsychiatric Drugs in the Context of Treating Cancer-Related Anorexia With Olanzapine and Mirtazapine
Clinical and Practical Psychopharmacology

August 21, 2024

Dr Andrade discusses two RCTs that investigated the utility of olanzapine and mirtazapine in addressing appetite loss in cancer patients.
Chittaranjan Andrade, MD
JCP
Aerobic Exercise: Randomized Controlled Trial Data Suggest Qualified Benefits for Erectile Dysfunction
Clinical and Practical Psychopharmacology

July 29, 2024

Dr Andrade discusses a recent meta-analysis indicating benefits of aerobic exercise in the primary prevention of erectile dysfunction.
Chittaranjan Andrade, MD
JCP
Epilepsy, Antiepileptic Drugs, and Adverse Pregnancy Outcomes, 2: Major Congenital Malformations With Antiepileptic Drug Monotherapy
Clinical and Practical Psychopharmacology

July 3, 2024

This article reviews evidence from a large registry, a population-based study, and a meta-analysis on the risks of major congenital malformation with untreated epilepsy and with exposure to antiepileptic...
Chittaranjan Andrade, MD

Review Article

JCP
The Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia: A Targeted Literature Review With a Focus on Outcomes Relevant to Health Care Decision-Makers in the United States
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
Christoph U. Correll, MD; Pin Xiang, PharmD, MS; Kaushik Sarikonda, PharmD, MS; Nikhil Bhagvandas, MS; Matthew Gitlin, PharmD

Narrative Review

JCP
Rationale for Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia
Narrative Review

August 19, 2024

While the pathophysiology of schizophrenia is complex, treatments with novel pharmacological actions that target these systems are of interest as adjunctive treatment for schizophrenia.
Bruce J. Kinon, MD; Stefan Leucht, MD; Carol Tamminga, MD; Alan Breier, MD; Ronald Marcus, MD; Steven M. Paul, MD
JCP
Immune-Targeted Therapies for Depression: Current Evidence for Antidepressant Effects of Monoclonal Antibodies
Narrative Review

June 24, 2024

Immune dysregulation may contribute to treatment resistance in depression. Monoclonal antibodies have shown promise in treating depression when used for inflammatory disorders and may offer new hope for patients...
Mina M. Rizk, MD; Lindsay Bolton, BS; Flurin Cathomas, MD, PhD; Helen He, MD, PhD; Scott J. Russo, PhD; Emma Guttman-Yassky, MD, PhD; J. John Mann, MD; James Murrough, MD, PhD

Original Research

JCP
Prevalence and Course of Unwanted, Intrusive Thoughts of Infant-Related Harm
Original Research

August 14, 2024

Although intrusive thoughts of accidental and intentional infant harm are a common and normative postpartum experience, they cause distress for many new mothers. Clinically significant symptoms that remain by...
Fanie Collardeau, PhD; Olivia L. U. Anglin, MD; Arianne Y. K. Albert, PhD; Jazlyn G. Mayhue, MD; Nichole Fairbrother, PhD
JCP
Differentiation Across Bipolar Disorder and Major Depressive Disorder by Whole-Night Polysomnographic Findings
Original Research

August 14, 2024

PSG-measured sleep abnormalities, such as reduced REM latency, may be a diagnostic differentiating factor between MDD and bipolar disorder.
Meihong Xiu, PhD; Wenxin Li, MS; Yu Lan, MS; Kaiwen Li, MS; Xiaoe Lang, MD, PhD
JCP
Initiating Aripiprazole Lauroxil: Post Hoc Analysis of Safety and Tolerability of 1-Day and 21-Day Regimens
Original Research

August 12, 2024

In separate studies of the two initiation methods, the numbers of people who had side effects were similar, and most side effects were mild.
Roger W. Sommi, PharmD, BCPP, FCCP; Stephen R. Saklad, PharmD, BCPP; Peter J. Weiden, MD; Daniel Still, PharmD, BCPP; Meihua Wang, PhD; Sergey Yagoda, MD, PhD
JCP
The 24-Year Course of Symptomatic Disorders in Patients With Borderline Personality Disorder and Personality-Disordered Comparison Subjects: Description and Prediction of Recovery From BPD
Original Research

August 7, 2024

Findings suggest that the absence of substance use disorders is the strongest predictor of achieving recovery from BPD.
Mary C. Zanarini, EdD; Frances R. Frankenburg, MD; Isabel V. Glass, BA; Garrett M. Fitzmaurice, ScD
JCP
Assessing the Predictive Validity of Early Post-injury CAPS-5 for Later Posttraumatic Stress Disorder Diagnosis
Original Research

August 5, 2024

A CAPS-5 score of ≥15 provided good predictive accuracy for subsequent PTSD development in the general injured population.
Jae-Min Kim, MD, PhD; Ju-Wan Kim, MD; Hee-Ju Kang, MD, PhD; Ju-Yeon Lee, MD, PhD; Hyunseok Jang, MD, PhD; Inseok Jeong, MD, PhD; Jung-Chul Kim, MD, PhD; Sung-Wan Kim, MD, PhD; Il-Seon Shin, MD, PhD
JCP
The Association Between Sleep Disturbances and Perceived Stress in Substance Use Disorder Treatment
Original Research

July 31, 2024

Higher stress was associated with more severe insomnia, and vice versa, both at treatment intake and over the course of treatment, regardless of primary substance.
Martin Hochheimer, PhD; Jennifer D. Ellis, PhD; Brion Maher, PhD; Justin C. Strickland, PhD; Jill A. Rabinowitz, PhD; David Wolinsky, MD; Andrew S. Huhn, PhD
JCP
Prescription Opioid Use Disorder Among Adults Reporting Prescription Opioid Use With or Without Misuse in the United States
Original Research

July 15, 2024

Of US adults using prescription opioids in the past year, 12.1% misused them, and 7.0% met criteria for prescription opioid use disorder.
Beth Han, MD, PhD, MPH; Christopher M. Jones, PharmD, DrPH, MPH; Emily B. Einstein, PhD; Deborah Dowell, MD, MPH; Wilson M. Compton, MD, MPE
JCP
Underdiagnosis, Undertreatment, and Noncompliance With Treatment in People Who Died by Suicide
Original Research

July 10, 2024

Depression was diagnosed prior to death in 18.6% of people with a major depressive episode who died by suicide. Antidepressants were prescribed in 21.5% of these individuals, but only...
Belén S. Martín-Moreno, MD; Julio Guija, MD, PhD; Mario Blanco, MD, PhD; Alejandro Porras-Segovia, MD, PhD; Víctor Pereira-Sánchez, MD, PhD; Enrique Baca-García, MD, PhD; Lucas Giner, MD, PhD
JCP
Effects of Low-Dose Ketamine Infusion on the Positive and Negative Domains of Hopelessness and Suicidal Thoughts
Original Research

July 8, 2024

A single infusion of low-dose ketamine resulted in a brief (~4 hour) yet significant reduction in hopelessness.
Wei-Chen Lin, MD; Mu-Hong Chen, MD, PhD; Tung-Ping Su, MD; Cheng-Ta Li, MD, PhD; Hui-Ju Wu, BSN; Shih-Jen Tsai, MD; Ya-Mei Bai, MD PhD; Wei-Chung Mao, MD, PhD; Pei-Chi Tu, MD PhD
JCP
Borderline Personality Disorder and Eating Disorders: Investigating the Role of Emotion Regulation
Original Research

July 3, 2024

Deficits in emotion regulation significantly predicted borderline personality disorder (BPD). Although eating disorders were not significantly predicted by emotion regulation deficits, they did predict BPD diagnoses.
Samantha C. Dashineau, MS; Caroline E. Balling, MS; Susan C. South, PhD; Mark Zimmerman, MD
JCP
Controlled Study of Metabolic Syndrome Among Offspring of Parents With Bipolar Disorder
Original Research

July 1, 2024

In offspring of parents with bipolar disorder, lower socioeconomic status and personal history of mood disorders were associated with greater risk of metabolic syndrome and its components.
Nidhi P. Kulkarni, MSc; Mikaela K. Dimick, PhD; Kody G. Kennedy, PhD; David A. Axelson, MD; Dara J. Sakolsky, MD, PhD; Rasim S. Diler, MD; Danella M. Hafeman, MD, PhD; Tina R. Goldstein, PhD; Kelly J. Monk, BSN, RN; Fangzi Liao, MS; John A. Merranko, MA; Boris Birmaher, MD; Benjamin I. Goldstein, MD, PhD
JCP
Association of Suicidal Status, Inflammation Markers, and Resting-State Functional Activity and Connectivity in Patients With Major Depressive Disorder
Original Research

June 26, 2024

Resting-state activity of the VLPFC was altered in suicide attempters, possibly contributing to language impairment and poor decision-making and cognitive control.
Emilie Olié, MD, PhD; Guillaume Clain, MSc; Manon Malestroit, MSc; Dimitri Fiedos, MSc; Fabrice Cognasse, PhD; Jeremy Deverdun, PhD; Emmanuelle Le Bars, PhD; Philippe Courtet, MD, PhD
JCP
Depression, Rumination, and Suicide Attempts in Adolescents With Mood Disorders: Sex Differences in This Relationship
Original Research

June 19, 2024

The authors found that in male adolescents, suicide attempts are mostly influenced by depressive symptoms. In female adolescents, depressive symptoms not only directly increase the risk of suicide attempts,...
Dianying Liu, MD, PhD; Gang Lei, MD, PhD; Dian Li, MD; Hongdong Deng, MD; Xiang Yang Zhang, MD, PhD; Yonghui Dang, MD, PhD
JCP
Efficacy and Safety of Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants: A Phase 3 Randomized Controlled Trial
Original Research

June 17, 2024

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
Maurizio Fava, MD; Stephen M. Stahl, MD, PhD; Luca Pani, MD; Sara De Martin, PhD; Andrew J. Cutler, MD; Vladimir Maletic, MD, MS; Charles W. Gorodetzky, MD, PhD; Frank J. Vocci, PhD; Frank L. Sapienza, MS; Thomas R. Kosten, MD; Cornelia Kröger, PhD; Paggard Champasa, PhD; Cedric O’Gorman, MD; Clotilde Guidetti, MD; Andrea Alimonti, MD; Stefano Comai, PhD; Andrea Mattarei, PhD; Franco Folli, MD; David Bushnell, MS; Sergio Traversa, PharmD; Charles E. Inturrisi, PhD; Paolo L. Manfredi, MD; Marco Pappagallo, MD
JCP
Prevalence and Trends in Cigarette Smoking With and Without Tobacco Use Disorder Among Adults in the United States: 2010–2021
Original Research

June 12, 2024

The prevalence of daily smoking with tobacco use disorder (TUD) was 10 times that of daily cigarette smoking without TUD. But even nondaily smoking can produce or sustain TUD,...
Joanna M. Streck, PhD; Maria A. Parker, PhD, MPH, MS; Raul Cruz, PhD; Rachel L. Rosen, PhD; Timothy B. Baker, PhD; Megan E. Piper, PhD; Andrea H. Weinberger, PhD

Letter to the Editor

JCP
Mental Health Assessments for Fetal Interventions
Letter to the Editor

June 24, 2024

The authors offer guidance and raise awareness about the intersection of maternal mental health and fetal interventions.
Sindhura Vangala, MD; Roy Williams Jr., MD; Cara M. Buskmiller, MD; Jessian L. Munoz, MD

Editorial

JCP
JCP’s Focus on Women’s Mental Health: Twenty Years and Counting
Editorial

June 17, 2024

On the anniversary of JCP’s Focus on Women’s Mental Health section, Marlene P. Freeman reflects on the past 20 years in women’s mental health care, including what has changed...
Marlene P. Freeman, MD

Celebrating
85 Years

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