Debate and Discussion: In the Treatment of Depression, Does Selectivity of Action Matter?

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Dr. Schatzberg: There are 2 overriding issues to be addressed. First is the question of whether there is evidence of differential efficacy for major depression between single-action drugs and drugs that inhibit reuptake of both serotonin and norepinephrine. Second is the question of how to design a trial to evaluate whether one drug has enhanced or superior efficacy over another based on mechanism of action.’ ‹’ ‹