Decreased Lipoprotein Lipase as a Risk Factor for Atypical Neuroleptic-Induced Hypertriglyceridemia

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Sir: Neuroleptics often increase appetite. This increased appetite can lead to severe hypertriglyceridemia in patients with uncommon congenital lipoprotein lipase (LPL) deficiency. During neuroleptic therapy, attention should be paid to the potential for severe hypertriglyceridemia (> 1000 mg/dL) that increases the risk of atherosclerosis and can cause fatal acute pancreatitis.^1,2‘ ‹