Delusions Associated With Quetiapine-Related Weight Redistribution

Letter to the Editor

Sir: There is established evidence that patients taking conventional antipsychotics tend to exhibit more central obesity than the general population. While there have been numerous case reports focusing on weight gain with novel antipsychotics, there have been no reports of weight redistribution with these medications. In the package insert for quetiapine, the manufacturers report only a 2% incidence in weight gain, and there is no mention of its effects on abdominal adiposity. We report 3 cases in which patients developed delusions associated with an increase in abdominal fat, with virtually no change in overall weight during quetiapine therapy.