Development of Subtle Psychotic Symptoms With Memantine: A Case Report

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Sir: Memantine is a medication that has been recentlyapproved in the United States for the treatment of moderateto-severe Alzheimer’s disease. It is a low-to-moderate affinity,noncompetitive N-methyl-D-aspartate (NMDA) antagonist.¹The use of other noncompetitive NMDA antagonists such asketamine and phencyclidine is known to produce psychoticsymptoms.^2,3‘ ‹