Differential Modulation of Cerebrospinal Fluid Neurotrophins in Patients With Atopic Dermatitis Who Attempted Suicide

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Sir: Controversy exists regarding the relationship that levelsof neurotrophins in cerebrospinal fluid (CSF) or brain have withdepression and/or suicide. Hock et al.¹ state that neurotrophin-3(NT-3) expression is elevated in elderly patients with depression,whereas Dwivedi et al.² report that messenger RNA levels ofbrain-derived neurotrophic factor (BDNF) were found, in postmortemexaminations, to be reduced in the brains of adults whocommitted suicide. On the other hand, Hadjiconstantinou et al.³state that plasma nerve growth factor (NGF) levels are elevatedin depressed subjects.’ ‹’ ‹