Dosing of Divalproex Extended Release

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Sir: I read with great interest the article by Bowden et al.¹ in the October 2006 issue of the Journal. This important study establishes the efficacy and safety of using divalproex sodium extended release (ER), a relatively new formulation of divalproex sodium, for treating acute mania. In that study, divalproex ER was initiated using a dose of 25 mg/kg rounded up to the nearest 500 mg.’ ‹