Duloxetine's Role in the Treatment of Depression and Associated Painful Physical Symptoms

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Sir: The recent letter by Leo¹ raises a number of questions concerning the role of antidepressants in the treatment of painful physical symptoms associated with depression and pain in nondepressed patients. The author focuses on published data for the antidepressant duloxetine and attempts to determine whether there is a role for duloxetine in chronic pain management. We wish to reply to points raised in the letter and add data that were not in the public domain at the time of the letter’s submission.