The Effects of Newer Antidepressants on Low-Density Lipoprotein Cholesterol Levels

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Sir: Nicholas et al.¹ must be commended for investigating atopic of major clinical importance, i.e., the effects of the newer antidepressants, such as mirtazapine, on serum levels of lowdensity lipoprotein cholesterol (LDL-C). Indeed, LDL-C levels are considered as an important predictor of cardiovascular events.² The authors showed a statistically nonsignificant increase of 3% in LDL-C in healthy controls after 4 weeks of mirtazapine treatment compared with placebo treatment and concluded that mirtazapine did not increase LDL-C levels.