Electroencephalographic Abnormalities Associated With Antidepressant Treatment: A Comparsion of Mirtazpine, Venlafaxine, Citalopram, Reboxetine, and Amitriptyline

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Sir: Abnormalities in electroencephalography (EEG) recordings may occur during treatment not only with antipsychotics, but also with antidepressants.^1,2 Mirtazapine and venlafaxine, 2 potent novel antidepressants that are regarded as being safer in terms of neurotoxic side effects compared to tricyclic antidepressants (TCAs), have recently been associated with a proconvulsant action.^3,4 To compare the occurrence of EEG abnormalities during mirtazapine and venlafaxine treatment with EEG changes during treatment with antidepressants of other substance classes, including TCAs, we retrospectively analyzed EEG recordings of 255 patients undergoing antidepressant monotherapy with mirtazapine, venlafaxine, citalopram, reboxetine, or amitriptyline.’ ‹’ ‹