Eosinophilia Indicating Subclinical Clozapine-Induced Pericarditis

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Sir: Literature on clozapine-induced pericarditis (CIP) is very rare. CIP usually presents as a very acute clinical picture with polyserositis or pericardial tamponade. We report on a schizophrenic patient with eosinophilia who developed CIP with no further clinical signs, obvious laboratory abnormalities, or pathologic electrocardiogram (ECG) alterations that could be clearly attributed to cardiac disease.’ ‹