Extrapyramidal Side Effects Associated With Aripiprazole Coprescription in 2 Patients

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Sir: Aripiprazole, a novel atypical antipsychotic with a unique mechanism of action,^1-3 appears to be effective and well tolerated in most schizophrenic patients.² However, there has been little systematic investigation of aripiprazole’s pharmacodynamic properties and side effect profile in the presence of other psychotropic agents, particularly in nonschizophrenic individuals.’ ‹’ ‹