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The Journal of Clinical Psychiatry is committedto informing its readers about the progress now being made in the scientific understanding, diagnosis, treatment,and prevention of Alzheimer’s disease. With thiscommitment in mind, the Journal announces its plan topublish from time to time special articles and sections aspart of a "Focus on Alzheimer’s Disease and Related Disorders"series. To inaugurate the series, this issue includesa report in which Andreas Papassotiropoulos, M.D., andhis colleagues implicate a cluster of cholesterol-relatedgenes in the vulnerability to late-onset Alzheimer’s diseaseand propose for subsequent research studies acholesterol-related genetic risk score to help characterizean individual’s vulnerability to this disorder.’ ‹’ ‹’ ‹