Galantamine and QTc Prolongation

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Sir: This letter is in response to the case report on the use of galantamine 24 mg/day in a 47-year-old schizophrenia patient that was associated with corrected QT interval (QTc) prolongation that resolved upon the discontinuation of galantamine.¹ The report noted that the patient was on a complex medical regimen which included several psychotropic drugs that may affect the QTc interval and that he suffered from hypertension, diabetes, and likely heart disease within the context of syndrome X. The authors also hypothesized about potential risks of QTc prolongation in elderly people suffering from Alzheimer’s disease.