Gastroesophageal Reflux as a Possible Result of Clozapine Treatment

Sir: Stoner and colleagues provided interesting and what they called "encouraging" reports of 2 full-term infants born to mothers taking clozapine. One 8-day-old infant had a seizure potentially due to clozapine, because the drug crosses the placenta. The same infant had evidence of gastroesophageal reflux, but diagnosis was uncertain owing to apparent concomitant gastroenteritis.