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This is the much-anticipated follow-up edition of a highly useful handbook that has served countless physicians over the past 2 decades. It is the immediate successor to Arana and Rosenbaum’s Handbook of Psychiatric Drug Therapy, 4th edition,1 which was published in 2000. In the 6-year interval, the book has grown in the number of authors (from 2 to 5) and in the number of pages (67 additional) and most notably has changed in its organization and mission.’ ‹