High-Dose Aripiprazole in Treatment-Resistant Schizophrenia

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Sir: Aripiprazole, a dopamine-serotonin system stabilizer, is the latest addition to the armamentarium of antipsychotics. The maximum recommended dose for aripiprazole per the Physicians’ Desk Reference is 30 mg/day.1 However, as gleaned from recent reports, other atypical antipsychotics have been used in doses higher than those recommended by the U.S. Food and Drug Administration (FDA).²‘ ‹