High-Dose Olanzapine Versus Clozapine

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Sir: The article by Meltzer and colleagues1 suggestingthat high-dose olanzapine may be equivalent to clozapine intreatment-resistant schizophrenics warrants some discussion.

The authors’ power analysis suggested that 17 patients pergroup would be sufficient to provide 80% power. However, thepower analysis (as is often the case) did not consider dropouts,and this was a particular concern in this study since 6 of 21 patientsreceiving clozapine dropped out prior to 6 weeks.’ ‹