Hyperglycemia Associated With Olanzapine

Sir: Olanzapine, a thienobenzodiazepine, is an atypical antipsychotic agent similar to clozapine, risperidone, and quetiapine in that it selectively binds to serotonin receptors. It also has an affinity for the D₂, D₄, D₁, muscarinic, α₁-adrenergic, and H₁ histaminic receptors. Olanzapine is well tolerated and has a safety profile associated with a low incidence of extrapyramidal movements and agranulocytosis.