Hypomanic Episodes After Receiving Ziprasidone: An Unintended "On-Off-On" Course of Treatment

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Sir: Thus far, 2 case studies have reported on a total of 6 patients with hypomania possibly induced by the atypical antipsychotic ziprasidone,1,2 although it should be noted that none of these published cases can prove that hypomania was caused by ziprasidone. Here, I present a case that may be seen as supportive of such a causal relation.