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Abstract CME Background Information Introduction Impact of DRP on Patients Impact of DRP on Carers Caregiver Interventions for DRP Conclusion Clinical Points References
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DELETE eReport November 3, 2020

Impact of Dementia-Related Psychosis on Patients and Caregivers: The Treatment Imperative

Dag Aarsland, MD, PhD

J Clin Psychiatry 2020;81(6):AD19038BR2C

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Find more articles on this and other psychiatry and CNS topics:
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Abstract

Behavioral and psychological symptoms are common in patients with dementia. Especially troublesome are the delusions and hallucinations of dementia-related psychosis (DRP) due to their negative impact on both patients and their carers and family members. This report reviews the impact of DRP on patients and carers, assessment tools, and coping strategies and techniques to help care partners manage DRP.

J Clin Psychiatry 2020;81(6):AD19038BR2C

Read the related Academic Highlights

From the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation and Institute of Psychiatry, Psychology & Neuroscience at King’s College London.
To cite: Aarsland D. Impact of dementia-related psychosis on patients and caregivers: the treatment imperative. J Clin Psychiatry. 2020;81(6):AD19038BR2C.
To share: https://doi.org/10.4088/JCP.AD19038BR2C
© Copyright 2020 Physicians Postgraduate Press, Inc.

CME Background Information

Target Audience

Neurologists, psychiatrists, nurse practitioners, and physician assistants

Learning Objectives

Discuss the impact of psychosis on patients with dementia with them (if possible) and their caregivers

Support Statement

Supported by an educational grant from ACADIA Pharmaceuticals Inc.

Learning Objective

After completing this educational activity, you should be able to:

  • Discuss the impact of psychosis on patients with dementia with them (if possible) and their caregivers

Release, Review, and Expiration Dates

This brief report activity was published in October 2020 and is eligible for AMA PRA Category 1 Credit™ through October 31, 2022. The latest review of this material was September 2020.

Statement of Need and Purpose

Hallucinations and delusions are key behaviors contributing to behavioral crises in patients with dementia, and a lack of consistency in assessment of behaviors has been found. Clinicians may lack awareness of the incidence of psychotic symptoms in different forms of dementia, as dementia pathology has been incorrectly diagnosed on the basis of the presence or absence of psychosis. Some patients may not be able to describe their psychotic symptoms, requiring caregiver input to aid clinicians in recognition. Rating scales can be implemented to aid identification. Clinicians need education about assessing patients with dementia for hallucinations and delusions and about the incidence of psychotic symptoms in different forms of dementia. In addition, many patients with dementia-related psychosis (DRP) receive antipsychotics and are on treatment for over a year, although guidelines recommend tapering after 4 months. Clinicians need education to implement guideline-concordant care that is tailored to the individual patient, incorporating current information on the risks and benefits of nonpharmacologic and pharmacologic interventions for DRP. This activity was designed to meet the needs of participants in CME activities provided by the CME Institute of Physicians Postgraduate Press, Inc., who have requested information on DRP.

Disclosure of Off-Label Usage

Dr Aarsland has determined that, to the best of his knowledge, no investigational information about pharmaceutical agents or device therapies that is outside US Food and Drug Administration–approved labeling has been presented in this activity.

Review Process

The faculty members agreed to provide a balanced and evidence-based presentation and discussed the topics and CME objectives during the planning sessions. The faculty’s submitted content was validated by CME Institute staff, and the activity was evaluated for accuracy, use of evidence, and fair balance by the Chair and a peer reviewer who is without conflict of interest.

Acknowledgment

This activity is derived from the teleconference series “Current Management Approaches for Insomnia,” which was held in May and June 2020 and supported by an educational grant from ACADIA Pharmaceuticals Inc. The opinions expressed herein are those of the faculty and do not necessarily reflect the opinions of the CME provider and publisher or the commercial supporter.

Faculty Affiliation

Dag Aarsland, MD, PhD
National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation and Institute of Psychiatry, Psychology & Neuroscience at King’s College London, UK

Financial Disclosure

The faculty for this CME activity and the CME Institute staff were asked to complete a statement regarding all relevant personal and financial relationships between themselves or their spouse/partner and any commercial interest. The Accreditation Council for Continuing Medical Education (ACCME) defines a commercial interest as any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients. The ACCME defines relevant financial relationships as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. The CME Institute has resolved any conflicts of interest that were identified. No member of the CME Institute staff reported any relevant personal financial relationships.

Dr Aarsland has received research support and/or honoraria from AstraZeneca, Lundbeck, Novartis, Biogen, and GE Health and served as a paid consultant for Lundbeck, Eisai, Heptares, and Mentis Cura. The Chair for this activity, Clive Ballard, MBChB, MMedSci, MRCPsych, MD, is a consultant for and has received honoraria from Acadia, Roche, Lundbeck, Exevia, AARP, Synexus, and Novo Nordisk; has received grant/research support from Synexus, Novo Nordisk; and is a member of the speakers/advisory boards for Acadia, Roche, AARP, Synexus, and Novo Nordisk.

Accreditation Statement

The CME Institute of Physicians Postgraduate Press, Inc., is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation

The CME Institute of Physicians Postgraduate Press, Inc., designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Note: The American Nurses Credentialing Center (ANCC) and the American Academy of Physician Assistants (AAPA) accept certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. To obtain credit for this activity, study the material and complete the CME Posttest and Evaluation.

Introduction

Behavioral and psychological symptoms are common in patients with dementia and include aggression, agitation, depression, and psychosis.1 Especially troublesome are the delusions and hallucinations of dementia-related psychosis (DRP) due to their negative impact on both patients and care partners. The ill effects of DRP include increased medical costs, care partner burden, and nursing home placement (AV 1).2–5 This report reviews the impact of DRP on patients and carers and provides coping strategies for carers.

AV 1. Impact of Psychosis

Data from Tampi and Tampi,2 Masopust et al,3 Casey,4 and Evans and Cotter.5

Impact of DRP on Patients

Cohen-Mansfield and colleagues6 analyzed the emotional and behavioral reactions of persons with dementia in relation to the delusions and hallucinations they experienced, based on family carer reports. The results showed that approximately half of the delusions resulted in discomfort while around 40% did not. Among the types of delusions, those related to abandonment, danger, and infidelity were associated with more discomfort than others. These findings highlight the need for clinicians to examine the emotional impact of delusions and hallucinations as part of patients’ assessment and as a consideration in treatment decisions.

Caregiver Perspectives

Caregivers have described both happy and fearful reactions of patients experiencing DRP:

“My Dad says he works for Congress and he is [President] Trump’s right-hand man. He tells me Trump calls him, and Trump thinks he is fantastic. My father never worked in politics.”7

“[My mother] recently had delusions/hallucinations of robbers/soldiers coming in through her window with guns, and she hid in the closet — not comfortably either.”7

Studies have examined outcomes for patients with DRP. For example, one study8 followed 456 patients with Alzheimer disease (AD) at early stages for up to 14 years and examined the time to cognitive and functional decline, institutionalization, and death. Delusions, which were present in 34% of patients at baseline and 70% at any visit, were associated with increased risk of cognitive and functional decline. Hallucinations were associated with not only more rapid cognitive and functional decline but also increased institutionalization and higher risk of death. Hallucinations were present in 7% of patients at baseline and 33% at any visit. Another study9 in patients with AD found that hallucinations, especially visual ones, were associated with more rapid cognitive decline and increased mortality. Thus, the presence of DRP indicates a more rapid disease progression of AD.

In addition to AD, DRP negatively impacts patients who have other types of dementia. For example, a study10 of individuals with Parkinson disease (PD) found that the presence of hallucinations was the strongest predictor of nursing home admission during the 4-year study period. Another study11 compared psychiatric symptoms and functional decline in patients newly diagnosed with AD and dementia with Lewy bodies (DLB) over 5 years. Those who had fewer neuropsychiatric symptoms (NPS) had milder functional impairment, both in the AD group and the DLB group. Of the NPS, delusions and aggression were the strongest predictors of a more rapid functional decline.

DRP also has a negative effect in patients with mild cognitive impairment (MCI). A study12 examined whether NPS were related to global functional impairment at baseline and over a 3-year period in normal older controls, subjects with MCI, and subjects with mild AD. At baseline, hallucinations, anxiety, and apathy were associated with greater global functional impairment. Baseline hallucinations and apathy were associated with greater global functional impairment during the 3-year period across all subjects.

Impact of DRP on Carers

DRP is associated with increased burden on care partners for several reasons. Delusions and hallucinations may directly impact the patient’s ability to perform cognitive and functional tasks,13 which can contribute to carer distress.14,15 Patients experiencing hallucinations, such as seeing a person in the house who should not be there, may run after “the person” or even call the police for help.

Additionally, although some psychotic symptoms might not be dramatic, they are often accompanied by troublesome affective and behavioral symptoms, such as agitation, aggression, depression, or irritability/anger, which can be stressful for the carer. Sleep disturbances associated with psychotic symptoms may not only lead to increased agitation and reduced daytime functioning in patients, which are challenging for carers to address, but also cause lack of sleep for carers.16 Furthermore, DRP is often treated with antipsychotics, which can have a range of negative effects on patients, including parkinsonism and tardive dyskinesia, contributing to carer burden.13

Psychotic symptoms can also adversely impact the emotional connection between the care partner and the patient.17 The partnership-relationship between the patient and the carer suffers due to the occurrence of dementia, and psychotic symptoms are particularly important in this regard.18 Patients who act out psychotic content, such as believing their spouse is having an affair, may get angry and even inflict physical threats toward or violence on the partner.17,19

Care Partner Perspective

One care partner described the danger of her husband’s delusions and hallucinations:

“My husband … would quickly whip out his cane to hit me, bite my daughter, twist my arm back in its socket, grab the steering wheel. He thought that I had a boyfriend who was trying to steal his money, that I was trying to poison him, and could see and hear all the people in the house who were plotting against him.”7

Of course, these risk factors for care partner distress are not mutually exclusive and can exist to varying degrees in different patients. Clinicians must be sure that carers also receive assessment and support along with the patient with dementia.15

Carer assessment. To measure the impact of DRP on care partners, several scales are available. The Zarit Burden Interview, a popular self-report measure, originated as a 29-item questionnaire.20 Shortened versions are available for faster administration.21 Carers are asked to rate each question on a 5-point scale ranging from 0 (Never) to 4 (Nearly Always).21,22 This scale includes questions such as: “Do you feel stressed between caring for your relative and trying to meet other work/family responsibilities?”23

The Relatives’ Stress Scale (RSS)24 is a self-rated, 15-item scale that measures the carer’s burden on a scale from 0 to 60, with a higher score indicating a higher degree of burden.25

The Neuropsychiatric Inventory Caregiver Distress Scale (NPI-D)26 links caregiver distress to every psychiatric symptom on the 12-item Neuropsychiatric Inventory (NPI), which includes delusions and hallucinations. If the symptom is present, the carer is asked for the frequency, the duration, and the extent to which that symptom is associated with distress. In a study27 that examined carer burden associated with BPSD using the NPI for patients with dementia and the NPI-D for their carers, delusions had the highest mean NPI-D score (3.2 ± 1.9).

Terum and colleagues14 conducted a similar analysis to determine whether specific NPS in patients with AD and DLB impacted carer distress. Distress was analyzed using the RSS, and patients’ symptoms were rated using the NPI. Apathy was the symptom most closely associated with higher carer distress overall; delusions were a significant contributor to carer distress in the DLB group.

Another way of measuring the impact of DRP is to consider the consequences of these symptoms, such as depression and burnout, in those caring for a person with dementia. A study28 that analyzed distress in carers of people with DLB and carers of people with AD found that 40% of those caring for people with DLB and 20% of those caring for people with AD experienced moderate or high burden, which increased the risk of psychiatric disorders.28 Carers of people with DLB also had a significantly higher RSS total score (19.9) compared with those caring for people with AD (15.0; P = .005). These results indicate that psychotic symptoms are key drivers of care partner burden.

Caregiver Interventions for DRP

As burdensome as DRP can be, not all delusions or hallucinations are problematic or disruptive for the patient or the care partner.

Caregiver Perspectives

One carer described nonharmful hallucinations his mother experienced:

“She lately thinks on occasion that she lives in England/Ireland (never been there even) or in Texas (which she visited quite a bit 40 some years ago). Doesn’t regularly believe that the house I bought last year is ours (it is). … I have no idea where they get this stuff, and it’s always quite surprising to see what they come up with next. Forgot to mention another one that keeps coming up: She thinks that both she and I are or have been in the military! (Neither is true.) She’ll ask me about the base or where I’m stationed and how long before I can retire with full benefits. She thinks we’ve lived all over the world.  (uh, no. not global travelers. Been to Mexico. Once. almost 30 years ago!).”29

However, when symptoms are distressing patients and negatively impacting carers, clinicians can offer interventions to help carers cope and useful techniques to manage DRP.19,30

Coping strategies. A common and effective coping strategy is to enhance the care partner’s ability to manage behavioral problems, including delusions, hallucinations, and agitation.31,32 Cognitive-behavioral therapy (CBT) helps carers avoid negative thoughts and employ constructive strategies. Psychoeducational strategies are frequently used to educate carers about dementia, communication, and management of troublesome behaviors. Interventions to support and educate carers may be delivered to individuals or to groups and may be provided in person or by telephone, email, or internet.31,32

Two main strategies for helping care partners cope with DRP are emotion-based and problem-focused interventions.31 Although both strategies have beneficial elements, the problem-focused strategies are typically more successful. Emotion-based strategies, such as using humor and ignoring unimportant issues, can have negative consequences for both patients and carers. In contrast, problem-focused strategies, such as learning about the condition, talking to others in similar situations, having a personal hobby, and following routines, are associated with lower carer strain and psychological comorbidity.

Case Practice Question

Bill has moderate-to-severe dementia due to Alzheimer disease. His wife and care partner Carol has coxarthrosis, mild general anxiety disorder, and impaired vision. Carol contacts you to say that the situation at home is getting more difficult because her husband is complaining that their neighbor is entering their home at night to have sex with her, which is not true. After confirming that Bill is not aggressive or violent toward Carol or the neighbor, what is the best next step to help Carol and Bill?
a. Administer a depression rating scale for Carol.
b. Find a nursing home for Bill to be admitted.
c. Prescribe an anxiolytic for Carol.
d. Direct Carol to a service offering counseling and support for carers of people with dementia.

Discussion of Case Practice Question

Preferred response: d. Direct Carol to a service offering counseling and support for carers of people with dementia.

Explanation: Counseling and support should provide coping strategies to help Carol handle the challenging behaviors associated with her husband’s dementia.31 Administering a depression scale for Carol or providing her with a prescription for anxiety is not a priority in this situation unless her RSS score is above 30.28 A nursing home may be required eventually but is usually not the first step to consider, especially if Bill’s symptoms follow a typical fluctuating course and he is not aggressive or threatening to Carol.

Techniques for carers to manage hallucinations. Coping with visual hallucinations presents a unique challenge to care partners; these symptoms can have substantial psychosocial effects on carers and contribute to nursing home placement.33 Care partners may ask clinicians about how to behave or what they should say when the patient sees and responds to visual hallucinations. A common yet unhelpful strategy is to argue and try to convince patients that what they are seeing is not real.34 Instead, carers may use visual, cognitive, or interactive techniques to help patients with hallucinations.33,35

Caregiver Perspective

Carers described going along with their parents’ hallucinations of living and dead relatives, children, and animals:

“I don’t mind going into her world with them most of the time, but I usually test the waters first and see if she is willing to consider she had a dream. If she says no, not a dream, then I go with her. … Redirection works sometimes but only for short periods of time if at all.”7

“He thinks that I’m a wonderful person who takes care of him, that I’m a pitcher for the Yankees and that children are floating on the ceiling. I can live with that. … Unless these hallucinations are either scary to [the patient] or dangerous for you, you can go along with it.”7

Conclusion

Psychotic symptoms are common in patients with dementia and are associated with more rapid cognitive and functional decline, high risk for institutionalization, and increased mortality. In terms of carer impact, DRP is often, although not always, related to increased burden, stress, and depression. Treatment may not only improve the distressing symptoms but also reduce the need for institutionalization and improve the quality of life for patients and carers. Clinicians must be prepared to offer strategies to care partners and family members, such as psychoeducation, CBT, and support, to help them cope with DRP and other behavioral symptoms.

Clinical Points

  • Recognize the negative outcomes related to DRP, including increased risk of cognitive and functional decline, nursing home admission, patient mortality, and carer stress.
  • Assess the stress and burden of DRP in both patients and care partners using appropriate rating scales.
  • Provide timely psychoeducation, support, and strategies to help carers better manage their loved ones’ delusions and hallucinations.

References

  1. Marcinkowska M, Śniecikowska J, Fajkis N, et al. Management of dementia-related psychosis, agitation and aggression: a review of the pharmacology and clinical effects of potential drug candidates. CNS Drugs. 2020;34(3):243–268. PubMed CrossRef
  2. Tampi RR, Tampi DJ. Managing Behavioral and Psychological Symptoms of Dementia. Psychiatric Times. https://www.psychiatrictimes.com/view/managing-behavioral-and-psychological-symptoms-dementia. Published March 20, 2020. Accessed July 27, 2020.
  3. Masopust J, Protopopová D, Vališ M, et al. Treatment of behavioral and psychological symptoms of dementias with psychopharmaceuticals: a review. Neuropsychiatr Dis Treat. 2018;14:1211–1220. PubMed CrossRef
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  5. Evans LK, Cotter VT. Avoiding restraints in patients with dementia: understanding, prevention, and management are the keys. Am J Nurs. 2008;108(3):40–49, quiz 50. PubMed CrossRef
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  7. Alzheimer’s Association. Delusions. alz connected website. https://www.alzconnected.org/discussion.aspx?g=posts&t=2147496914. Published 2013. Accessed September 14, 2020.
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  35. Diederich NJ, Pieri V, Goetz CG. Coping strategies for visual hallucinations in Parkinson’s disease. Mov Disord. 2003;18(7):831–832. PubMed CrossRef

© Copyright 2020 Physicians Postgraduate Press, Inc.

This CME activity is expired. For more CME activities, visit CMEInstitute.com.
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders

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