Increased Lithium Concentrations Reported in Patients Treated With Sulindac

Letter to the Editor

Sir: Lithium continues to be a primary treatment of choice in bipolar disorder; however, the use of this mood stabilizer requires close monitoring owing to a narrow therapeutic range. Equally important is the close monitoring of adverse drug reactions and toxicity resulting from concomitant medications. A specific association with increased lithium concentrations has been established for nonsteroidal anti-inflammatory drugs (NSAIDs). Several reports in the literature support the idea that concomitant NSAID administration raises lithium concentrations.