Increasing Energy Expenditure Is Important to Enhance Management of Antipsychotic-Associated Weight Gain

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Sir: We thank the editors for the opportunity to respond tothe letter by Sharpe and colleagues. We would like to start bystating that we are in complete agreement with them that, theoretically,increasing energy expenditure is important in the managementof weight gain, whether induced by antipsychotics ornot. Furthermore, on the basis of studies in non-psychiatricallyill populations, increased energy expenditure might be predictedto be even more important in the maintenance of weightloss.¹‘ ‹