Back to top Open menu arrow
The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

The Journal of
Clinical Psychiatry
Access icon

This article is available to members only. Please enjoy the abstract for free. Subscribe for instant access to the full article.

This content is restricted to subscribers

Continue Reading...

Did you know members enjoy unlimited free PDF downloads as part of their subscription? Subscribe today for instant access to this article and our entire library in your preferred format. Alternatively, you can purchase the PDF of this article individually.

Subscribe Now

Already a member? Login

  1. Department of Radiology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China
  2. These authors contributed equally.
  3. Laboratory of Neuropsychology and Laboratory of Social Cognitive Affective Neuroscience, Department of Psychology, University of Hong Kong, Hong Kong
  4. These authors contributed equally.
  5. Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China
  6. Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China
  7. Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, China
  8. Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China
  9. Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China
  10. Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, Shandong Province, China
  11. Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China ‡These authors contributed equally. *Corresponding author: Kangguang Lin, MD, PhD, Department of Affective Disorder, The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Rd, Guangzhou, Guangdong Province 510370, China ([email protected]).
  12. Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China
  13. Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, Shandong Province, China
  14. Corresponding author: Kangguang Lin, MD, PhD, Department of Affective Disorder, The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Rd, Guangzhou, Guangdong Province 510370, China ([email protected]).
  1. Vieta E, Salagre E, Grande I, et al. Early intervention in bipolar disorder. Am J Psychiatry. 2018;175(5):411–426. PubMed CrossRef
  2. Post RM, Altshuler LL, Kupka R, et al. Illnesses in siblings of US patients with bipolar disorder relate to multigenerational family history and patients severity of illness. J Affect Disord. 2017;207:313–319. PubMed CrossRef
  3. Berk M, Berk L, Dodd S, et al. Stage managing bipolar disorder. Bipolar Disord. 2014;16(5):471–477. PubMed CrossRef
  4. Lin K, Shao R, Lu R, et al. Resting-state fMRI signals in offspring of parents with bipolar disorder at the high-risk and ultra-high-risk stages and their relations with cognitive function. J Psychiatr Res. 2018;98:99–106. PubMed CrossRef
  5. Doucet GE, Bassett DS, Yao N, et al. The role of intrinsic brain functional connectivity in vulnerability and resilience to bipolar disorder. Am J Psychiatry. 2017;174(12):1214–1222. PubMed CrossRef
  6. Bora E, Özerdem A. Meta-analysis of longitudinal studies of cognition in bipolar disorder: comparison with healthy controls and schizophrenia. Psychol Med. 2017;47(16):2753–2766. PubMed CrossRef
  7. Pagliaccio D, Wiggins JL, Adleman NE, et al. Behavioral and neural sustained attention deficits in bipolar disorder and familial risk of bipolar disorder. Biol Psychiatry. 2017;82(9):669–678. PubMed CrossRef
  8. Brady RO Jr, Tandon N, Masters GA, et al. Differential brain network activity across mood states in bipolar disorder. J Affect Disord. 2017;207:367–376. PubMed CrossRef
  9. Schneider MR, DelBello MP, McNamara RK, et al. Neuroprogression in bipolar disorder. Bipolar Disord. 2012;14(4):356–374. PubMed CrossRef
  10. Van Meter AR, Burke C, Youngstrom EA, et al. The bipolar prodrome: meta-analysis of symptom prevalence prior to initial or recurrent mood episodes. J Am Acad Child Adolesc Psychiatry. 2016;55(7):543–555. PubMed CrossRef
  11. Lin K, Lu R, Chen K, et al. Differences in cognitive deficits in individuals with subthreshold syndromes with and without family history of bipolar disorder. J Psychiatr Res. 2017;91:177–183. PubMed CrossRef
  12. Bonnin CM, Torrent C, Vieta E, et al. Restoring functioning in bipolar disorder: functional remediation. Harv Rev Psychiatry. 2014;22(6):326–330. PubMed CrossRef
  13. Queissner R, Pilz R, Dalkner N, et al. The relationship between inflammatory state and quantity of affective episodes in bipolar disorder. Psychoneuroendocrinology. 2018;90:61–67. PubMed CrossRef
  14. Nusslock R, Brody GH, Armstrong CC, et al. Higher peripheral inflammatory signaling associated with lower resting-state functional brain connectivity in emotion regulation and central executive networks. Biol Psychiatry. 2019;86(2):153–162. PubMed CrossRef
  15. Huang TL, Lin FC. High-sensitivity C-reactive protein levels in patients with major depressive disorder and bipolar mania. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(2):370–372. PubMed CrossRef
  16. Wysokiński A, Margulska A, Strzelecki D, et al. Levels of C-reactive protein (CRP) in patients with schizophrenia, unipolar depression and bipolar disorder. Nord J Psychiatry. 2015;69(5):346–353. PubMed CrossRef
  17. Chung KH, Huang SH, Wu JY, et al. The link between high-sensitivity C-reactive protein and orbitofrontal cortex in euthymic bipolar disorder. Neuropsychobiology. 2013;68(3):168–173. PubMed CrossRef
  18. Misiak B, Stańczykiewicz B, Kotowicz K, et al. Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: a systematic review. Schizophr Res. 2018;192:16–29. PubMed CrossRef
  19. Rosenblat JD, McIntyre RS. Bipolar disorder and inflammation. Psychiatr Clin North Am. 2016;39(1):125–137. PubMed CrossRef
  20. Dantzer R, Cohen S, Russo SJ, et al. Resilience and immunity. Brain Behav Immun. 2018;74:28–42. PubMed CrossRef
  21. Dargél AA, Godin O, Kapczinski F, et al. C-reactive protein alterations in bipolar disorder: a meta-analysis. J Clin Psychiatry. 2015;76(2):142–150. PubMed CrossRef
  22. Gu Y, Vorburger R, Scarmeas N, et al. Circulating inflammatory biomarkers in relation to brain structural measurements in a non-demented elderly population. Brain Behav Immun. 2017;65:150–160. PubMed CrossRef
  23. Janowitz D, Habes M, Toledo JB, et al. Inflammatory markers and imaging patterns of advanced brain aging in the general population. Brain Imaging Behav. 2020;14(4):1108–1117. PubMed CrossRef
  24. Dargél AA, Godin O, Etain B, et al; FACE-BD collaborators. Emotional reactivity, functioning, and C-reactive protein alterations in remitted bipolar patients: clinical relevance of a dimensional approach. Aust N Z J Psychiatry. 2017;51(8):788–798. PubMed CrossRef
  25. Parker KL, Kim YC, Kelley RM, et al. Delta-frequency stimulation of cerebellar projections can compensate for schizophrenia-related medial frontal dysfunction. Mol Psychiatry. 2017;22(5):647–655. PubMed CrossRef
  26. Toma S, MacIntosh BJ, Swardfager W, et al. Cerebral blood flow in bipolar disorder: a systematic review. J Affect Disord. 2018;241:505–513. PubMed CrossRef
  27. Corlier F, Hafzalla G, Faskowitz J, et al. Systemic inflammation as a predictor of brain aging: contributions of physical activity, metabolic risk, and genetic risk. Neuroimage. 2018;172:118–129. PubMed CrossRef
  28. Dickerson F, Stallings C, Origoni A, et al. Elevated C-reactive protein and cognitive deficits in individuals with bipolar disorder. J Affect Disord. 2013;150(2):456–459. PubMed CrossRef
  29. Lin K, Shao R, Wang R, et al. Inflammation, brain structure and cognition interrelations among individuals with differential risks for bipolar disorder. Brain Behav Immun. 2020;83:192–199. PubMed CrossRef
  30. Meier TB, Drevets WC, Wurfel BE, et al. Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain Behav Immun. 2016;53:39–48. PubMed CrossRef
  31. Tsai SY, Gildengers AG, Hsu JL, et al. Inflammation associated with volume reduction in the gray matter and hippocampus of older patients with bipolar disorder. J Affect Disord. 2019;244:60–66. PubMed CrossRef
  32. Balukova SM, Haarman BC, Riemersma-van der Lek RF, et al. Does CRP predict outcome in bipolar disorder in regular outpatient care? Int J Bipolar Disord. 2016;4(1):14. PubMed CrossRef
  33. Lin K, Xu G, Wong NM, et al. A multi-dimensional and integrative approach to examining the high-risk and ultra-high-risk stages of bipolar disorder. EBioMedicine. 2015;2(8):919–928. PubMed CrossRef
  34. Dodd S, Williams LJ, Jacka FN, et al. Reliability of the Mood Disorder Questionnaire: comparison with the Structured Clinical Interview for the DSM-IV-TR in a population sample. Aust N Z J Psychiatry. 2009;43(6):526–530. PubMed CrossRef
  35. Kaufman J, Birmaher B, Brent DA, et al. K-SADS-PL. J Am Acad Child Adolesc Psychiatry. 2000;39(10):1208. PubMed CrossRef
  36. Correll CU, Penzner JB, Frederickson AM, et al. Differentiation in the preonset phases of schizophrenia and mood disorders: evidence in support of a bipolar mania prodrome. Schizophr Bull. 2007;33(3):703–714. PubMed CrossRef
  37. Williams JB, Kobak KA, Bech P, et al. The GRID-HAMD: standardization of the Hamilton Depression Rating Scale. Int Clin Psychopharmacol. 2008;23(3):120–129. PubMed CrossRef
  38. Thompson E. Hamilton Rating Scale for Anxiety (HAM-A). Occup Med (Lond). 2015;65(7):601. PubMed CrossRef
  39. Favre S, Aubry JM, Gex-Fabry M, et al. Translation and validation of a French version of the Young Mania Rating Scale (YMRS). Encephale. 2003;29(6):499–505. PubMed
  40. Schooler NR. Precursors to the PANSS: The BPRS and its progenitors. Innov Clin Neurosci. 2017;14(11-12):10–11. PubMed
  41. Wiederholt JL, Rees FJ. A description of the comprehensive test of nonverbal intelligence. J Child Neurol. 1998;13(5):224–228. PubMed CrossRef
  42. Cornblatt BA, Risch NJ, Faris G, et al. The Continuous Performance Test, identical pairs version (CPT-IP), I: new findings about sustained attention in normal families. Psychiatry Res. 1988;26(2):223–238. PubMed CrossRef
  43. Hayes A. Introduction to mediation, moderation, and conditional process analysis. J Educ Meas. 2013;51(3):335–337.
  44. Preacher KJ, Hayes AF. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods. 2008;40(3):879–891. PubMed CrossRef
  45. Hamdani N, Doukhan R, Kurtlucan O, et al. Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications. Curr Psychiatry Rep. 2013;15(9):387. PubMed CrossRef
  46. Boukouaci W, Oliveira J, Etain B, et al. Association between CRP genetic diversity and bipolar disorder comorbid complications. Int J Bipolar Disord. 2018;6(1):4. PubMed CrossRef
  47. Fernandes BS, Steiner J, Molendijk ML, et al. C-reactive protein concentrations across the mood spectrum in bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry. 2016;3(12):1147–1156. PubMed CrossRef
  48. Tanaka T, Matsuda T, Hayes LN, et al. Infection and inflammation in schizophrenia and bipolar disorder. Neurosci Res. 2017;115:59–63. PubMed CrossRef
  49. Lin K, Shao R, Geng X, et al. Illness, at-risk and resilience neural markers of early-stage bipolar disorder. J Affect Disord. 2018;238:16–23. PubMed CrossRef
  50. Tsai SY, Chung KH, Chen PH. Levels of interleukin-6 and high-sensitivity C-reactive protein reflecting mania severity in bipolar disorder. Bipolar Disord. 2017;19(8):708–709. PubMed CrossRef
  51. Hwang S, White SF, Nolan ZT, et al. Neurodevelopmental changes in the responsiveness of systems involved in top down attention and emotional responding. Neuropsychologia. 2014;62:277–285. PubMed CrossRef
  52. Felger JC, Li Z, Haroon E, et al. Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Mol Psychiatry. 2016;21(10):1358–1365. PubMed CrossRef
  53. Goldstein BI, Collinger KA, Lotrich F, et al. Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders. J Child Adolesc Psychopharmacol. 2011;21(5):479–484. PubMed CrossRef
  54. Dooley LN, Ganz PA, Cole SW, et al. Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer. J Affect Disord. 2016;197:43–50. PubMed CrossRef
  55. Carniel BP, da Rocha NS. Brain-derived neurotrophic factor (BDNF) and inflammatory markers: Perspectives for the management of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021;108:110151. PubMed CrossRef
  56. Laumet G, Edralin JD, Chiang AC, et al. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology. 2018;43(13):2597–2605. PubMed CrossRef
  57. Dhabhar FS. Effects of stress on immune function: the good, the bad, and the beautiful. Immunol Res. 2014;58(2-3):193–210. PubMed CrossRef
  58. Rosenblat JD, Brietzke E, Mansur RB, et al. Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: evidence, pathophysiology and treatment implications. J Affect Disord. 2015;188:149–159. PubMed CrossRef
  59. Nielsen MO, Petersen NA, Coello K, et al. High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons: results from a clinical study. Eur Psychiatry. 2020;63(1):e103. PubMed CrossRef
  60. Christ A, Lauterbach M, Latz E. Western diet and the immune system: an inflammatory connection. Immunity. 2019;51(5):794–811. PubMed CrossRef
  61. González Olmo BM, Butler MJ, Barrientos RM. Evolution of the human diet and its impact on gut microbiota, immune responses, and brain health. Nutrients. 2021;13(1):196. PubMed CrossRef
  62. Lee AH, Dixit VD. Dietary regulation of immunity. Immunity. 2020;53(3):510–523. PubMed CrossRef

Save Save

Share Share

Cite Cite

Read the Current Issue

Vol 85, 2024 3

Can Our Collective Experiences As Clinicians Improve Mental Health Care?

SSRI Discontinuation and AUD Relapse

Reproductive Pharmacovigilance and Best Practices

Olanzapine and Mirtazapine for Cancer-Related Anorexia

Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia

Functional Unblinding in Pivotal Studies and the Future of Psychedelic Medicine
View current Issue

Celebrating
85 Years

Read the Journal of Clinical Psychiatry

Subscribe to read
more articles

Subscribe