Injection Site Pain With Long-Acting Risperidone

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.’ ‹

Sir: In a recent report in the Journal,¹ only 1 of 141 patientsin a 12-week multicenter trial of injectable long-acting risperidonecomplained of pain at the site of injection, which was mild.Pain at the injection site has been noted to be a problem withfirst-generation antipsychotics.^2,3 The authors speculated thatthe water-based formulation of risperidone might account forthe low frequency of injection site pain. In a previous study,⁴patient ratings of pain on a visual analogue scale after injectionsof long-acting risperidone were similar to ratings of pain afterinjections of placebo after the first and sixth injections.’ ‹