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In this supplement, each article focuses on a different aspect of atypical depression. First, Jonathan R. T. Davidson, M.D., examines the evolution of the concept of atypical depression; second, Gordon B. Parker, M.D., Ph.D., D.Sc., discusses the validity of the current concept and suggests a new model for viewing atypical depression from a personality spectrum perspective; third, Jonathan W. Stewart, M.D., presents a review of the treatment literature, focusing on established therapies and ending with the work on selective serotonin reuptake inhibitors (SSRIs); and finally, Mark H. Rapaport, M.D., considers newer perspectives on treatment of atypical depression and evaluates recent therapy developments. This brief overview touches on the topics that each author addresses.’ ‹